Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Although cancer is a diverse set of diseases, cancer cells share a number of adaptive
hallmarks. Dysregulated pH is emerging as a hallmark of cancer because cancers show …

This white paper discusses prospects for advancing hyperpolarization technology to better
understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13 C …

A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic
constraints imposed by the serine and glycine–limited brain environment restrict metastatic …

Hyperpolarized (HP) carbon 13 (13C) MRI is an emerging molecular imaging method that
allows rapid, noninvasive, and pathway-specific investigation of dynamic metabolic and …

Pancreatic ductal adenocarcinoma is on pace to become the second leading cause of
cancer-related death. The high mortality rate results from a lack of methods for early …

A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …

A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer
patients using 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized …

Monocarboxylates such as lactate, pyruvate, and the ketone bodies play major roles in
metabolism and must be transported across both the plasma membrane and mitochondrial …