Epigenetics and aging
S Pal, JK Tyler - Science advances, 2016 - science.org
Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …
to epigenetic information accompany aging in both dividing and nondividing cells …
FOXO transcription factors as mediators of stress adaptation
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
Genome-wide RNA polymerase stalling shapes the transcriptome during aging
A Gyenis, J Chang, JJPG Demmers, ST Bruens… - Nature …, 2023 - nature.com
Gene expression profiling has identified numerous processes altered in aging, but how
these changes arise is largely unknown. Here we combined nascent RNA sequencing and …
these changes arise is largely unknown. Here we combined nascent RNA sequencing and …
Ageing-associated changes in transcriptional elongation influence longevity
C Debès, A Papadakis, S Grönke, Ö Karalay, LS Tain… - Nature, 2023 - nature.com
Physiological homeostasis becomes compromised during ageing, as a result of impairment
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …
of cellular processes, including transcription and RNA splicing,,–. However, the molecular …
[HTML][HTML] Individual cell types in C. elegans age differently and activate distinct cell-protective responses
Aging is characterized by a global decline in physiological function. However, by
constructing a complete single-cell gene expression atlas, we find that Caenorhabditis …
constructing a complete single-cell gene expression atlas, we find that Caenorhabditis …
BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy
Aging clocks dissociate biological from chronological age. The estimation of biological age
is important for identifying gerontogenes and assessing environmental, nutritional, or …
is important for identifying gerontogenes and assessing environmental, nutritional, or …
aaUrgent Needs of Caregiving in Ageing Populations with Alzheimer's Disease and Other Chronic Conditions: Support Our Loved Ones
The ageing process begins at birth. It is a life-long process, and its exact origins are still
unknown. Several hypotheses attempt to describe the normal ageing process, including …
unknown. Several hypotheses attempt to describe the normal ageing process, including …
Cockayne syndrome: Clinical features, model systems and pathways
AC Karikkineth, M Scheibye-Knudsen, E Fivenson… - Ageing research …, 2017 - Elsevier
Cockayne syndrome (CS) is a disorder characterized by a variety of clinical features
including cachectic dwarfism, severe neurological manifestations including microcephaly …
including cachectic dwarfism, severe neurological manifestations including microcephaly …
Age‐dependent changes and biomarkers of aging in Caenorhabditis elegans
Caenorhabditis elegans is an exceptionally valuable model for aging research because of
many advantages, including its genetic tractability, short lifespan, and clear age‐dependent …
many advantages, including its genetic tractability, short lifespan, and clear age‐dependent …
Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells
Understanding the aging process and ways to manipulate it is of major importance for
biology and medicine. Among the many aging theories advanced over the years, the …
biology and medicine. Among the many aging theories advanced over the years, the …