Protein–protein interactions involving voltage-gated sodium channels: post-translational regulation, intracellular trafficking and functional expression
D Shao, K Okuse, MBA Djamgoz - … journal of biochemistry & cell biology, 2009 - Elsevier
Voltage-gated sodium channels (VGSCs), classically known to play a central role in
excitability and signalling in nerves and muscles, have also been found to be expressed in a …
excitability and signalling in nerves and muscles, have also been found to be expressed in a …
Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics?
O Knapp, JR McArthur, DJ Adams - Toxins, 2012 - mdpi.com
Voltage-gated sodium channels (VGSC) are the primary mediators of electrical signal
amplification and propagation in excitable cells. VGSC subtypes are diverse, with different …
amplification and propagation in excitable cells. VGSC subtypes are diverse, with different …
Changes in the expression of NaV1. 7, NaV1. 8 and NaV1. 9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic …
IT Strickland, JC Martindale, PL Woodhams… - European journal of …, 2008 - Elsevier
Voltage-gated sodium channels play an essential role in regulating the excitability of
nociceptive primary afferent neurones. In particular the tetrodotoxin-sensitive (TTX-S) NaV1 …
nociceptive primary afferent neurones. In particular the tetrodotoxin-sensitive (TTX-S) NaV1 …
A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins
S Peigneur, L Béress, C Möller, F Marí… - The FASEB …, 2012 - Wiley Online Library
APETx3, a novel peptide isolated from the sea anemone Anthopleura elegantissima, is a
naturally occurring mutant from APETx1, only differing by a Thr to Pro substitution at position …
naturally occurring mutant from APETx1, only differing by a Thr to Pro substitution at position …
Immortalization and characterization of a nociceptive dorsal root ganglion sensory neuronal line
Abstract Development of neuroprotective strategies for peripheral neuropathies requires
high‐throughput drug screening assays with appropriate cell types. Currently, immortalized …
high‐throughput drug screening assays with appropriate cell types. Currently, immortalized …
Antisense-Mediated Knockdown of NaV1.8, but Not NaV1.9, Generates Inhibitory Effects on Complete Freund's Adjuvant-Induced Inflammatory Pain in Rat
YQ Yu, F Zhao, SM Guan, J Chen - PLoS One, 2011 - journals.plos.org
Tetrodotoxin-resistant (TTX-R) sodium channels NaV1. 8 and NaV1. 9 in sensory neurons
were known as key pain modulators. Comparing with the widely reported NaV1. 8, roles of …
were known as key pain modulators. Comparing with the widely reported NaV1. 8, roles of …
Ca2+-Permeable AMPA Receptors Contribute to Changed Dorsal Horn Neuronal Firing and Inflammatory Pain
The dorsal horn (DH) neurons of the spinal cord play a critical role in nociceptive input
integration and processing in the central nervous system. Engaged neuronal classes and …
integration and processing in the central nervous system. Engaged neuronal classes and …
Conotoxin modulation of voltage-gated sodium channels
The rising phase of the action potential in excitable cells is mediated by voltage-gated
sodium channels (VGSCs), of which there are nine mammalian subtypes with distinct tissue …
sodium channels (VGSCs), of which there are nine mammalian subtypes with distinct tissue …
Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider …
In the present study, we investigated the structure and function of hainantoxin-III (HNTX-III), a
33-residue polypeptide from the venom of the spider Ornithoctonus hainana. It is a selective …
33-residue polypeptide from the venom of the spider Ornithoctonus hainana. It is a selective …
An update on proficiency of voltage-gated ion channel blockers in the treatment of inflammation-associated diseases
Inflammation is the body's mechanism to trigger the immune system, thereby preventing
bacteria and viruses from manifesting their toxic effect. Inflammation plays a vital role in …
bacteria and viruses from manifesting their toxic effect. Inflammation plays a vital role in …