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The role of voltage-gated sodium channels in pain signaling
Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …
The physiological function of different voltage-gated sodium channels in pain
Evidence from human genetic pain disorders shows that voltage-gated sodium channel α-
subtypes Nav1. 7, Nav1. 8 and Nav1. 9 are important in the peripheral signalling of pain …
subtypes Nav1. 7, Nav1. 8 and Nav1. 9 are important in the peripheral signalling of pain …
Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura
Migraine is a complex neurovascular disease with a range of severity and symptoms, yet
mostly studied as one phenotype in genome-wide association studies (GWAS). Here we …
mostly studied as one phenotype in genome-wide association studies (GWAS). Here we …
Voltage-gated sodium channels: structure, function, pharmacology, and clinical indications
M de Lera Ruiz, RL Kraus - Journal of medicinal chemistry, 2015 - ACS Publications
The tremendous therapeutic potential of voltage-gated sodium channels (Navs) has been
the subject of many studies in the past and is of intense interest today. Nav1. 7 channels in …
the subject of many studies in the past and is of intense interest today. Nav1. 7 channels in …
Advances in understanding nociception and neuropathic pain
Pain results from the activation of a subset of sensory neurones termed nociceptors and has
evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory …
evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory …
Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain
Distinct types of dorsal root ganglion sensory neurons may have unique contributions to
chronic pain. Identification of primate sensory neuron types is critical for understanding the …
chronic pain. Identification of primate sensory neuron types is critical for understanding the …
[HTML][HTML] Toward a mechanism-based approach to pain diagnosis
The past few decades have witnessed a huge leap forward in our understanding of the
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …
mechanistic underpinnings of pain, in normal states where it helps protect from injury, and …
Physiology and pathophysiology of itch
Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …
understood and appreciated. The pathophysiological consequences of itch impact quality of …
Pathology of pain and its implications for therapeutic interventions
B Cao, Q Xu, Y Shi, R Zhao, H Li, J Zheng… - … and Targeted Therapy, 2024 - nature.com
Pain is estimated to affect more than 20% of the global population, imposing incalculable
health and economic burdens. Effective pain management is crucial for individuals suffering …
health and economic burdens. Effective pain management is crucial for individuals suffering …
Status of peripheral sodium channel blockers for non-addictive pain treatment
The effective and safe treatment of pain is an unmet health-care need. Current medications
used for pain management are often only partially effective, carry dose-limiting adverse …
used for pain management are often only partially effective, carry dose-limiting adverse …