KSHV LANA—the master regulator of KSHV latency

T Uppal, S Banerjee, Z Sun, SC Verma, ES Robertson - Viruses, 2014 - mdpi.com
Kaposi's sarcoma associated herpesvirus (KSHV), like other human herpes viruses,
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …

Pathologic angiogenesis of malignant vascular sarcomas: implications for treatment

JA Khan, RG Maki, V Ravi - Journal of Clinical Oncology, 2018 - ascopubs.org
Angiosarcoma, epithelioid hemangioendothelioma, and Kaposi sarcoma are classified
according to the line of differentiation that these neoplastic cells most closely resemble: the …

Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS

G Zhang, B Chan, N Samarina… - Proceedings of the …, 2016 - National Acad Sciences
The latency-associated nuclear antigen (LANA) of Kaposi sarcoma herpesvirus (KSHV) is
mainly localized and functions in the nucleus of latently infected cells, playing a pivotal role …

Kaposi's sarcoma-associated herpesvirus: epidemiology and molecular biology

S Li, L Bai, J Dong, R Sun, K Lan - Infectious Agents Associated Cancers …, 2017 - Springer
Kaposi's sarcoma-associated herpesvirus (KSHV), also known as Human herpesvirus 8
(HHV-8), is a member of the lymphotropic gammaherpesvirus subfamily and a human …

Lung cancer gene regulatory network of transcription factors related to the hallmarks of cancer

BA Otálora-Otálora, L López-Kleine… - Current Issues in Molecular …, 2023 - mdpi.com
The transcriptomic analysis of microarray and RNA-Seq datasets followed our own
bioinformatic pipeline to identify a transcriptional regulatory network of lung cancer. Twenty …

Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen: More than a key mediator of viral persistence

TF Schulz, A Freise, SC Stein - Current Opinion in Virology, 2023 - Elsevier
Kaposi sarcoma-associated herpesvirus (KSHV), or human herpesvirus-8, is an oncogenic
herpesvirus. Its latency-associated nuclear antigen (LANA) is essential for the persistence of …

TLR4-mediated inflammation promotes KSHV-induced cellular transformation and tumorigenesis by activating the STAT3 pathway

M Gruffaz, K Vasan, B Tan, S Ramos da Silva, SJ Gao - Cancer research, 2017 - AACR
Toll-like receptors (TLR) are conserved immune sensors mediating antimicrobial and
antitumoral responses, but recent evidence implicates them in promoting carcinogenesis in …

Hepatitis B virus core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein …

B Jia, M Guo, G Li, D Yu, X Zhang, K Lan… - Journal of …, 2015 - Am Soc Microbiol
Hepatitis B, which caused by hepatitis B virus (HBV) infection, remains a major health threat
worldwide. Hepatic injury and regeneration from chronic inflammation are the main driving …

Molecular biology of KSHV in relation to HIV/AIDS-associated oncogenesis

M He, F Cheng, SR da Silva, B Tan, O Sorel… - HIV/AIDS-Associated …, 2019 - Springer
Discovered in 1994, Kaposi's sarcoma-associated herpesvirus (KSHV) has been associated
with four human malignancies including Kaposi's sarcoma, primary effusion lymphoma, a …

KSHV RTA Induces Degradation of the Host Transcription Repressor ID2 To Promote the Viral Lytic Cycle

LR Combs, LMK Spires, JD Alonso, B Papp… - Journal of …, 2022 - Am Soc Microbiol
The immediate early viral protein replication and transcription activator (RTA) of Kaposi's
sarcoma-associated herpesvirus (KSHV) is essential for activating the lytic cycle of KSHV …