GDF15, an emerging key player in human aging

M Conte, C Giuliani, A Chiariello, V Iannuzzi… - Ageing research …, 2022 - Elsevier
Abstract Growth differentiation factor 15 (GDF15) is recently emerging not only as a stress-
related mitokine, but also as a key player in the aging process, being one of the most up …

Phylogenetics is the new genetics (for most of biodiversity)

SD Smith, MW Pennell, CW Dunn… - Trends in Ecology & …, 2020 - cell.com
Despite substantial progress in understanding the genetic basis for differences in
morphology, physiology, and behavior, many phenotypes of interest are difficult to study with …

Life in deserts: The genetic basis of mammalian desert adaptation

JL Rocha, R Godinho, JC Brito, R Nielsen - Trends in Ecology & Evolution, 2021 - cell.com
Deserts are among the harshest environments on Earth. The multiple ages of different
deserts and their global distribution provide a unique opportunity to study repeated …

Antagonistic pleiotropy in human disease

SG Byars, K Voskarides - Journal of Molecular Evolution, 2020 - Springer
Between the 1930s and 1950s, scientists developed key principles of population genetics to
try and explain the aging process. Almost a century later, these aging theories, including …

Pan-mammalian analysis of molecular constraints underlying extended lifespan

A Kowalczyk, R Partha, NL Clark, M Chikina - Elife, 2020 - elifesciences.org
Although lifespan in mammals varies over 100-fold, the precise evolutionary mechanisms
underlying variation in longevity remain unknown. Species-specific genetic changes have …

Transcription factors evolve faster than their structural gene targets in the flavonoid pigment pathway

LC Wheeler, JF Walker, J Ng, R Deanna… - Molecular Biology …, 2022 - academic.oup.com
Dissecting the relationship between gene function and substitution rates is key to
understanding genome-wide patterns of molecular evolution. Biochemical pathways provide …

The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS

JD Orkin, MJ Montague… - Proceedings of the …, 2021 - National Acad Sciences
Ecological flexibility, extended lifespans, and large brains have long intrigued evolutionary
biologists, and comparative genomics offers an efficient and effective tool for generating new …

Genome evolution and the future of phylogenomics of non-avian reptiles

DC Card, WB Jennings, SV Edwards - Animals, 2023 - mdpi.com
Simple Summary As a group of organisms, non-avian reptiles, most of which are the~
11,000 species of lizards and snakes, are an extraordinarily diverse group, displaying a …

A multibreed genome-wide association study for cattle leukocyte telomere length

AV Igoshin, NS Yudin, GA Romashov, DM Larkin - Genes, 2023 - mdpi.com
Telomeres are terminal DNA regions of chromosomes that prevent chromosomal fusion and
degradation during cell division. In cattle, leukocyte telomere length (LTL) is associated with …

Comparative genomics reveals convergent signals associated with the high metabolism and longevity in birds and bats

Y Matsuda, T Makino - Proceedings of the Royal Society …, 2024 - royalsocietypublishing.org
Birds and bats have long lifespans relative to their body size compared with non-flying
animals. However, the genomic basis associated with longer lifespan of flying species …