Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Background The CYP11B2 gene (CYP11B2) encoding aldosterone synthase has been
associated with essential hypertension and some, but not all, studies have reported that the …

A thymidine-to-cytosine substitution in the–344 promoter region of the aldosterone synthase
gene (CYP11B2) has been associated with essential hypertension in some but not all …

Genome-wide association studies significantly increased the number of hypertension risk
variants; however, most of them focused on European societies. There is lack of such …

Methods: The study was conducted in 406 hypertensive cases and 424 healthy controls from
Tamil population. Genoty** was performed by PCR-restriction fragment length …

ABSTRACT Background: Aldosterone synthase (CYP11B2) is a key enzyme involved in the
terminal steps of aldosterone biosynthesis. Genetic variability in CYP11B2 gene has been …

Background Aldosterone can affect both blood pressure (BP) and glucose metabolism. We
assessed the association of two polymorphisms− 344 T> C and the 3097 G> A in the …

Background: It has been suggested that the− 344C/T polymorphism in the CYP11B2 gene is
involved in the development of hypertension. However, the results have been inconsistent …

Objective: A meta-analysis was carried out to evaluate the correlation between CYP11B2-
344C/T polymorphism and essential hypertension susceptibility. Methods: By retrieving …

Essential hypertension (EH) is a complex multifactorial condition influenced by both genetic
and environmental factors; aldosterone synthase (CYP11B2) is a key enzyme which …