Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …

Histology permits the observation of otherwise invisible structures of the internal topography
of a specimen. Although it enables the investigation of tissues at a cellular level, it is invasive …

Electrophysiological studies of excitable organs usually focus on action potential (AP)-
generating cells, whereas nonexcitable cells are generally considered as barriers to …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Patient-specific computer models have been developed representing a variety of aspects of
the cardiovascular system spanning the disciplines of electrophysiology, electromechanics …

The bidomain equations are widely used for the simulation of electrical activity in cardiac
tissue. They are especially important for accurately modeling extracellular stimulation, as …

In order to simulate the cardiac function for a patient‐specific geometry, the generation of the
computational mesh is crucially important. In practice, the input is typically a set of …

The heart is a nonlinear biological system that can exhibit complex electrical dynamics,
complete with period-doubling bifurcations and spiral and scroll waves that can lead to …

One of the most recent trends in cardiac electrophysiology is the development of integrative
anatomically accurate models of the heart, which include description of cardiac activity from …

The combination of computational models and biophysical simulations can help to interpret
an array of experimental data and contribute to the understanding, diagnosis and treatment …