Secretome analysis: Reading cellular sign language to understand intercellular communication
W Wu, J Krijgsveld - Molecular & Cellular Proteomics, 2024 - ASBMB
A significant portion of mammalian proteomes is secreted to the extracellular space to fulfill
crucial roles in cell-to-cell communication. To best recapitulate the intricate and multi-faceted …
crucial roles in cell-to-cell communication. To best recapitulate the intricate and multi-faceted …
Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice
Immune response genes are highly polymorphic in humans and mice, with heterogeneity
amongst loci driving strain-specific host defence responses. The inadvertent retention of …
amongst loci driving strain-specific host defence responses. The inadvertent retention of …
Proteomic Characterization of Urinary Exosomes with Pancreatic Cancer by Phosphatidylserine Imprinted Polymer Enrichment and Mass Spectrometry Analysis
X Cheng, W Yu, Y Liu, S Jia, D Wang… - Journal of Proteome …, 2024 - ACS Publications
Exosomes, as carriers of cell-to-cell communication, can serve as promising biomarkers for
probing the early diagnosis of cancer. Pancreatic cancer is a common malignant tumor of …
probing the early diagnosis of cancer. Pancreatic cancer is a common malignant tumor of …
Pancreatic ductal adenocarcinoma microenvironment: soluble factors and cancer associated fibroblasts as modulators of NK cell functions
Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is the most frequent pancreatic cancer
and represents one of the most aggressive human neoplasms. Typically identified at …
and represents one of the most aggressive human neoplasms. Typically identified at …
Map** functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer
Intratumor morphological heterogeneity of pancreatic ductal adenocarcinoma (PDAC)
predicts clinical outcomes but is only partially understood at the molecular level. To …
predicts clinical outcomes but is only partially understood at the molecular level. To …
Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome
D Sridharan, JA Dougherty, U Ahmed… - Stem Cell Research & …, 2024 - Springer
Background Human induced pluripotent stem cells (hiPSCs) and their differentiated cell
types have a great potential for tissue repair and regeneration. While the primary focus of …
types have a great potential for tissue repair and regeneration. While the primary focus of …
Secreted LGALS3BP facilitates distant metastasis of breast cancer
SS Kim, I Park, J Kim, NL Ka, GY Lim, MY Park… - Breast Cancer …, 2025 - Springer
Background Patients with estrogen receptor (ER)-positive breast cancer (BC) can be treated
with endocrine therapy targeting ER, however, metastatic recurrence occurs in 25% of the …
with endocrine therapy targeting ER, however, metastatic recurrence occurs in 25% of the …
Colon mucosal proteomics of ankylosing spondylitis versus gut inflammation
M Cheng, S **ao, S Kayi, Y Guan, Y Liu, J Chen… - Plos one, 2024 - journals.plos.org
Objective Ankylosing spondylitis (AS) patients often present with microscopic signs of gut
inflammation. We used proteomic techniques to identify the differentially expressed proteins …
inflammation. We used proteomic techniques to identify the differentially expressed proteins …
CD47-mediated immune evasion in early-stage lung cancer progression
CH Chuang, YY Zhen, JY Ma, TH Lee, HY Hung… - Biochemical and …, 2024 - Elsevier
Alveolar and interstitial macrophages play crucial roles in eradicating pathogens and
transformed cells in the lungs. The immune checkpoint CD47, found on normal and …
transformed cells in the lungs. The immune checkpoint CD47, found on normal and …
The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells
Objective Pancreatic ductal adenocarcinoma (PDAC) has limited therapeutic options,
particularly with immune checkpoint inhibitors. Highly chemoresistant 'stem-like'cells, known …
particularly with immune checkpoint inhibitors. Highly chemoresistant 'stem-like'cells, known …