Emerging biomaterials for tumor immunotherapy

M **ao, Q Tang, S Zeng, Q Yang, X Yang… - Biomaterials …, 2023 - spj.science.org
Background The immune system interacts with cancer cells in various intricate ways that can
protect the individual from overproliferation of cancer cells; however, these interactions can …

Injectable hydrogels for personalized cancer immunotherapies

N Mohaghegh, A Ahari, F Zehtabi, C Buttles, S Davani… - Acta Biomaterialia, 2023 - Elsevier
The field of cancer immunotherapy has shown significant growth, and researchers are now
focusing on effective strategies to enhance and prolong local immunomodulation. Injectable …

An injectable and active hydrogel induces mutually enhanced mild magnetic hyperthermia and ferroptosis

X Chen, H Wang, J Shi, Z Chen, Y Wang, S Gu, Y Fu… - Biomaterials, 2023 - Elsevier
Magnetic hyperthermia therapy (MHT) is a promising new modality to deal with solid tumors,
yet the low magnetic-heat conversion efficacy, magnetic resonance imaging (MRI) artifacts …

ATP‐responsive smart hydrogel releasing immune adjuvant synchronized with repeated chemotherapy or radiotherapy to boost antitumor immunity

L Sun, F Shen, L Tian, H Tao, Z **ong, J Xu… - Advanced …, 2021 - Wiley Online Library
Certain chemotherapeutics and forms of ionizing radiation can induce immunogenic cell
death (ICD). If there simultaneously exist immune adjuvants within the tumor, such antitumor …

Nanomedicine‐based immunotherapy for the treatment of cancer metastasis

P Zhang, Y Zhai, Y Cai, Y Zhao, Y Li - Advanced Materials, 2019 - Wiley Online Library
Metastasis is the leading cause of cancer‐associated death, with poor prognosis even after
extensive treatment. The dormancy of metastatic cancer cells during dissemination or after …

Injectable anti-inflammatory nanofiber hydrogel to achieve systemic immunotherapy post local administration

M Chen, Y Tan, Z Dong, J Lu, X Han, Q **, W Zhu… - Nano …, 2020 - ACS Publications
Despite the great promise achieved by immune checkpoint blockade (ICB) therapy in
harnessing the immune system to combat different tumors, limitations such as low objective …

[HTML][HTML] Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy

S Han, J Wu - Bioactive Materials, 2022 - Elsevier
Though increasing understanding and remarkable clinical successes have been made,
enormous challenges remain to be solved in the field of cancer immunotherapy. In this …

Degradation-regulated architecture of injectable smart hydrogels enhances humoral immune response and potentiates antitumor activity in human lung carcinoma

HTT Duong, T Thambi, Y Yin, SH Kim, TL Nguyen… - Biomaterials, 2020 - Elsevier
Cancer vaccines that elicit a robust and durable antitumor response show great promise in
cancer immunotherapy. Nevertheless, low immunogenicity and weak immune response limit …

Multifunctional drug-loaded micelles encapsulated in thermo-sensitive hydrogel for in vivo local cancer treatment: Synergistic effects of anti-vascular and immuno …

HF Darge, EY Hanurry, YS Birhan… - Chemical Engineering …, 2021 - Elsevier
Localized cancer therapy with combination of drugs is an effective treatment modality which
increase inhibition of tumor growth and reoccurrence. Recently, hydrogels that can …

[HTML][HTML] Polymer-based hydrogels with local drug release for cancer immunotherapy

Z **e, J Shen, H Sun, J Li, X Wang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Immunotherapy that boosts the body's immune system to treat local and distant metastatic
tumors has offered a new treatment option for cancer. However, cancer immunotherapy via …