Toll-like receptor-guided therapeutic intervention of human cancers: molecular and immunological perspectives

S Mukherjee, R Patra, P Behzadi, A Masotti… - Frontiers in …, 2023 - frontiersin.org
Toll-like receptors (TLRs) serve as the body's first line of defense, recognizing both
pathogen-expressed molecules and host-derived molecules released from damaged or …

Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting

R Rimal, P Desai, R Daware, A Hosseinnejad… - Advanced drug delivery …, 2022 - Elsevier
The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …

[HTML][HTML] Tumor microenvironment of hepatocellular carcinoma: challenges and opportunities for new treatment options

Z Sas, E Cendrowicz, I Weinhäuser… - International Journal of …, 2022 - mdpi.com
The prevalence of liver cancer is constantly rising, with increasing incidence and mortality in
Europe and the USA in recent decades. Among the different subtypes of liver cancers …

[HTML][HTML] Cancer-associated fibroblasts in hepatocellular carcinoma and cholangiocarcinoma

F Ying, MSM Chan, TKW Lee - Cellular and Molecular Gastroenterology …, 2023 - Elsevier
Primary liver cancer (PLC) includes hepatocellular carcinoma and intrahepatic
cholangiocarcinoma and is the sixth most common cancer worldwide with poor prognosis …

Multicompartment Polyion Complex Micelles Based on Triblock Polypept (o) ides Mediate Efficient siRNA Delivery to Cancer‐Associated Fibroblasts for Antistromal …

P Schneider, H Zhang, L Simic, Z Dai… - Advanced …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and the
third leading cause for cancer‐related death worldwide. The tumor is difficult‐to‐treat due to …

Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators …

Y Zhou, W Tang, H Zhuo, D Zhu, D Rong, J Sun… - …, 2022 - Taylor & Francis
Chemoresistance in hepatocellular carcinoma (HCC) has been found to be influenced by
exosomal transport of circRNAs. However, the role of circZFR in HCC chemoresistance still …

Hypoxia-induced signaling in gut and liver pathobiology

S Solanki, YM Shah - Annual Review of Pathology: Mechanisms …, 2024 - annualreviews.org
Oxygen (O2) is essential for cellular metabolism and biochemical reactions. When the
demand for O2 exceeds the supply, hypoxia occurs. Hypoxia-inducible factors (HIFs) are …

Hypoxia signaling in hepatocellular carcinoma: Challenges and therapeutic opportunities

SQ Sin, CD Mohan, RMWJ Goh, M You… - Cancer and Metastasis …, 2023 - Springer
Hepatocellular carcinoma (HCC) is one of the most common cancers with a relatively high
cancer-related mortality. The uncontrolled proliferation of HCC consumes a significant …

Critical signaling pathways governing hepatocellular carcinoma behavior; small molecule-based approaches

Z Farzaneh, M Vosough, T Agarwal… - Cancer cell international, 2021 - Springer
Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer.
Although there are different treatment options, these strategies are not efficient in terms of …

Profiling of syngeneic mouse HCC tumor models as a framework to understand anti–PD‐1 sensitive tumor microenvironments

DJ Zabransky, L Danilova, JM Leatherman… - Hepatology, 2023 - journals.lww.com
Hepatology AASLD Publications Hepatology Liver Transplantation Hepatology Communications
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