Research from over the past 20 years has implicated dipeptidyl peptidase (DPP) IV and its
family members in many processes and different pathologies of the immune system. Most …

Abstract Background Proline specific peptidases (PSPs) are a unique group of enzymes that
specifically cleave bonds formed by a proline residue. The study of PSPs is important due to …

Fibroblast activation protein (FAP) is a serine protease related to dipeptidyl peptidase IV
(DPPIV). It has been convincingly linked to multiple disease states involving remodeling of …

All animals can perform certain survival behaviors without prior experience, suggesting a
“hard wiring” of underlying neural circuits. Experience, however, can alter the expression of …

We recently demonstrated that prenatal exposure to valproic acid (VPA) at embryonic day
12.5 causes autism spectrum disorder (ASD)-like phenotypes such as hypolocomotion …

The overexpression of fibroblast activation protein-α (FAP) in solid cancers relative to levels
in normal tissues has led to its recognition as a target for delivering agents directly to tumors …

In the aging brain, the correct balance of neural transmission and its regulation is of
particular significance, and neuropeptides have a significant role. Prolyl oligopeptidase …

Prolyl oligopeptidase (POP) is a conserved serine protease belonging to proline-specific
peptidases. It has both enzymatic and non-enzymatic activity and is involved in numerous …

Current treatments for Alzheimer's disease (AD) help reduce symptoms for a limited time but
do not treat the underlying pathology. To identify potential therapeutic targets for AD, an …

Presynaptic congenital myasthenic syndromes (CMS) are a group of genetic disorders
affecting the presynaptic side of the neuromuscular junctions (NMJ). They can result from a …