Insights on the mechanism of bleomycin to induce lung injury and associated in vivo models: a review

BL Ayilya, A Balde, M Ramya, S Benjakul… - International …, 2023 - Elsevier
Acute lung injury leads to the development of chronic conditions such as idiopathic
pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), asthma as well as …

Systematic characterization of the components and molecular mechanisms of **shui Huanxian granules using UPLC-Orbitrap Fusion MS integrated with network …

J Yuan, D Zhao, XF Liu, YG Tian, HJ Zhang… - Scientific Reports, 2022 - nature.com
**shui Huanxian granules (JSHX) is a clinical Chinese medicine formula used for treating
pulmonary fibrosis (PF). However, the effective components and molecular mechanisms of …

Evaluation of microRNA expression in a sheep model for lung fibrosis

UE Perera, HB Derseh, SNV Dewage, A Stent… - BMC genomics, 2021 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibroproliferative
disorder that has one of the poorest prognoses amongst interstitial lung diseases. Recently …

The efficacy and safety of pinocembrin in a sheep model of bleomycin-induced pulmonary fibrosis

HB Derseh, JQD Goodger, JPY Scheerlinck… - Plos one, 2021 - journals.plos.org
The primary flavonoid, pinocembrin, is thought to have a variety of medical uses which relate
to its reported anti-oxidant, anti-inflammatory, anti-microbial and anti-cancer properties …

Increased Levels of ER Stress and Apoptosis in a Sheep Model for Pulmonary Fibrosis Are Alleviated by In Vivo Blockade of the KCa3.1 Ion Channel

UE Perera, L Organ, SNV Dewage… - Canadian …, 2021 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease, characterized by
progressive damage to the lung tissues. Apoptosis and endoplasmic reticulum stress (ER …

[HTML][HTML] Effect of fluorofenidone against paraquat-induced pulmonary fibrosis based on metabolomics and network pharmacology

F Jiang, T Wang, S Li, Y Jiang, Z Chen… - Medical Science Monitor …, 2021 - ncbi.nlm.nih.gov
Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics
and Network Pharmacology - PMC Back to Top Skip to main content NIH NLM Logo Access …

Small airway remodeling in a sheep model of bleomycin-induced pulmonary fibrosis

HB Derseh, SNV Dewage, UE Perera… - Experimental Lung …, 2020 - Taylor & Francis
Background Although IPF is described traditionally as a disease affecting lung parenchyma,
there is renewed interest in the alterations in the structure and function of the small airways …

Exploring the mechanism of Gentiana rigescens Franch. in the treatment of pulmonary fibrosis based on network pharmacology

H Ming-xing, S Yan-Qiu, G Peng-Fei, L Hai-feng… - SN Applied …, 2023 - Springer
Pulmonary fibrosis (PF) is a severe chronic interstitial lung disease with high mortality, and
there is currently a lack of definite and effective treatment methods. Studies have found that …

Pirfenidone ameliorated AGE-induced EMT and attenuated peritoneal fibrosis in peritoneal mesothelial cells

X Fenglin, W Shengyuan, Z Zhiyong, Y Hai… - Molecular & Cellular …, 2021 - Springer
Background Peritoneal dialysis has greatly improved patient survival for patients with
chronic kidney disease. However, peritoneal fibrosis is a progressive fibrotic peritoneal …

Exploring the Mechanism of Gentiana rigescens in the Treatment of Pulmonary Fibrosis (PF) Based on Network Pharmacology

M Hu, YQ Song, PF Gao, HF Li, WH Liu - 2023 - researchsquare.com
Background Pulmonary fibrosis (PF) is a severe chronic interstitial lung disease with high
mortality, and there is currently a lack of definite and effective treatment methods. Studies …