Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
BDNF-induced local protein synthesis and synaptic plasticity
G Leal, D Comprido, CB Duarte - Neuropharmacology, 2014 - Elsevier
Brain-derived neurotrophic factor (BDNF) is an important regulator of synaptic transmission
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …
and long-term potentiation (LTP) in the hippocampus and in other brain regions, playing a …
[HTML][HTML] Translational control of long-lasting synaptic plasticity and memory
Long-lasting forms of synaptic plasticity and memory are dependent on new protein
synthesis. Recent advances obtained from genetic, physiological, pharmacological, and …
synthesis. Recent advances obtained from genetic, physiological, pharmacological, and …
Internal ribosome entry sites in eukaryotic mRNA molecules
CUT Hellen, P Sarnow - Genes & development, 2001 - genesdev.cshlp.org
Initiation of translation of most eukaryotic mRNAs commences with 5 end–dependent
recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator …
recruitment of 40S ribosomal subunits to the mRNA. The 40S subunit carrying the initiator …
Regulation of hippocampal synaptic plasticity by BDNF
G Leal, PM Afonso, IL Salazar, CB Duarte - Brain research, 2015 - Elsevier
The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …
Translational control by MAPK signaling in long-term synaptic plasticity and memory
RJ Kelleher, A Govindarajan, HY Jung, H Kang… - Cell, 2004 - cell.com
Enduring forms of synaptic plasticity and memory require new protein synthesis, but little is
known about the underlying regulatory mechanisms. Here, we investigate the role of MAPK …
known about the underlying regulatory mechanisms. Here, we investigate the role of MAPK …
Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile‐X syndrome: a quantitative examination
SA Irwin, B Patel, M Idupulapati… - American journal of …, 2001 - Wiley Online Library
Fragile‐X syndrome is a common form of mental retardation resulting from the inability to
produce the fragile‐X mental retardation protein. Qualitative examination of human brain …
produce the fragile‐X mental retardation protein. Qualitative examination of human brain …
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
Many forms of long-lasting behavioral and synaptic plasticity require the synthesis of new
proteins. For example, long-term potentiation (LTP) that endures for more than an hour …
proteins. For example, long-term potentiation (LTP) that endures for more than an hour …
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration
CA Saura, SY Choi, V Beglopoulos, S Malkani… - Neuron, 2004 - cell.com
Mutations in presenilins are the major cause of familial Alzheimer's disease, but the
pathogenic mechanism by which presenilin mutations cause memory loss and …
pathogenic mechanism by which presenilin mutations cause memory loss and …
GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine
A single, low dose of the NMDA receptor antagonist ketamine produces rapid
antidepressant actions in treatment-resistant depressed patients. Understanding the cellular …
antidepressant actions in treatment-resistant depressed patients. Understanding the cellular …