The rapid replication of HIV-1 and the errors made during viral replication cause the virus to
evolve rapidly in patients, making the problems of vaccine development and drug therapy …

Fluorescence provides a mechanism for achieving contrast in biological imaging that
enables investigations of molecular structure, dynamics, and function at high spatial and …

Highly fluorescent conjugated polymer dots were developed for demanding applications
such as fluorescence imaging in live cells. These nanoparticles exhibit small particle …

Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average,
these pathogens share little sequence similarity and use different replication and …

Nucleic acid aptamers are single-stranded DNA or RNA molecules identified to recognize
with high affinity specific targets including proteins, small molecules, ions, whole cells and …

Epigenetics and epigenomic medicine encompass a new science of brain and behavior that
are already providing unique insights into the mechanisms underlying brain development …

Single-molecule FRET has been widely used for monitoring protein–nucleic acids
interactions. Direct visualization of the interactions, however, often requires a site-specific …

Single-molecule fluorescence microscopy is uniquely suited for detecting transient
molecular recognition events, yet achieving the time resolution and statistics needed to …

The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic
acid structures so that the most thermodynamically stable conformations are formed. This …

The ATP-dependent chromatin assembly and remodelling factor (ACF) functions to generate
regularly spaced nucleosomes, which are required for heritable gene silencing. The …