Clinical implications of T cell exhaustion for cancer immunotherapy
Immunotherapy has been a remarkable clinical advancement in the treatment of cancer. T
cells are pivotal to the efficacy of current cancer immunotherapies, including immune …
cells are pivotal to the efficacy of current cancer immunotherapies, including immune …
Exploring immunotherapy in colorectal cancer
J Weng, S Li, Z Zhu, Q Liu, R Zhang, Y Yang… - Journal of hematology & …, 2022 - Springer
Chemotherapy combined with or without targeted therapy is the fundamental treatment for
metastatic colorectal cancer (mCRC). Due to the adverse effects of chemotherapeutic drugs …
metastatic colorectal cancer (mCRC). Due to the adverse effects of chemotherapeutic drugs …
[HTML][HTML] Serotonin reduction in post-acute sequelae of viral infection
Post-acute sequelae of COVID-19 (PASC," Long COVID") pose a significant global health
challenge. The pathophysiology is unknown, and no effective treatments have been found to …
challenge. The pathophysiology is unknown, and no effective treatments have been found to …
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Naïve CD8+ T cells can differentiate into effector (Teff), memory (Tmem) or exhausted (Tex)
T cells. These developmental pathways are associated with distinct transcriptional and …
T cells. These developmental pathways are associated with distinct transcriptional and …
Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
T cell exhaustion limits antitumor immunity, but the molecular determinants of this process
remain poorly understood. Using a chronic stimulation assay, we performed genome-wide …
remain poorly understood. Using a chronic stimulation assay, we performed genome-wide …
Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
The two T cell inhibitory receptors PD-1 and TIM-3 are co-expressed during exhausted T cell
differentiation, and recent evidence suggests that their crosstalk regulates T cell exhaustion …
differentiation, and recent evidence suggests that their crosstalk regulates T cell exhaustion …
[HTML][HTML] MYB orchestrates T cell exhaustion and response to checkpoint inhibition
CD8+ T cells that respond to chronic viral infections or cancer are characterized by the
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …
CRISPR–Cas12-based detection of SARS-CoV-2
JP Broughton, X Deng, G Yu, CL Fasching… - Nature …, 2020 - nature.com
An outbreak of betacoronavirus severe acute respiratory syndrome (SARS)-CoV-2 began in
Wuhan, China in December 2019. COVID-19, the disease associated with SARS-CoV-2 …
Wuhan, China in December 2019. COVID-19, the disease associated with SARS-CoV-2 …
Targeting the epigenetic regulation of antitumour immunity
Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …
cancer onset and progression. Although defective gene regulation often affects oncogenic …
Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms
CD8+ T cell exhaustion is a major barrier to current anti-cancer immunotherapies. Despite
this, the developmental biology of exhausted CD8+ T cells (Tex) remains poorly defined …
this, the developmental biology of exhausted CD8+ T cells (Tex) remains poorly defined …