Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Importance Psychiatric diagnoses are currently distinguished based on sets of specific
symptoms. However, genetic and clinical analyses find similarities across a wide variety of …

Major depressive disorder (MDD) is a debilitating disease that is characterized by
depressed mood, diminished interests, impaired cognitive function and vegetative …

Anhedonia is considered a core feature of major depressive disorder, and the dopamine
system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic …

We introduce the Mindboggle-101 dataset, the largest and most complete set of free,
publicly accessible, manually labeled human brain images. To manually label the …

Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …

Mindboggle (http://mindboggle. info) is an open source brain morphometry platform that
takes in preprocessed T1-weighted MRI data and outputs volume, surface, and tabular data …

Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

The neuro-anatomical substrates of major depressive disorder (MDD) are still not well
understood, despite many neuroimaging studies over the past few decades. Here we …