The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Stress is a primary risk factor for several neuropsychiatric disorders. Evidence from
preclinical models and clinical studies of depression have revealed an array of structural …

Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

Anhedonia is considered a core feature of major depressive disorder, and the dopamine
system plays a pivotal role in the hedonic deficits described in this disorder. Dopaminergic …

Mindboggle (http://mindboggle. info) is an open source brain morphometry platform that
takes in preprocessed T1-weighted MRI data and outputs volume, surface, and tabular data …

Enhancing neurogenesis within the hippocampal dentate gyrus (DG) is critical for
maintaining brain development and function in many neurological diseases. However, the …

Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both
systems likewise contribute to pathophysiology of depression. Recent findings demonstrate …

Importance Psychiatric diagnoses are currently distinguished based on sets of specific
symptoms. However, genetic and clinical analyses find similarities across a wide variety of …

Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …