Isoquinoline alkaloids, an important class of N‐based heterocyclic compounds, have
attracted considerable attention from researchers worldwide since the early 19th century …

Obesity is a significant health concern, as it causes a massive cascade of chronic
inflammations and multiple morbidities. Rheumatoid arthritis and osteoarthritis are chronic …

Background Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease,
which affects approximately 1% adult population in the worldwide. Aim The present study …

Norisoboldine (NOR), a natural aryl hydrocarbon receptor (AhR) agonist, has been
demonstrated to attenuate ulcerative colitis (UC) and induce the generation of Treg cells …

Lindera aggregata (Sims) Kosterm.(L. aggregata), which belongs to the genus Lindera in the
family Lauraceae, is widely distributed in Asia and the temperate, tropical regions of North …

Ethnopharmacological relevance Dried root tubers of L. aggregata have been widely used
in Chinese herbal medicine for thousands of years to promote qi, relieve pain, warm kidney …

Background Rheumatoid arthritis (RA) is an autoimmune disease that may be associated
with gut microbiota via the aryl hydrocarbon receptor (AhR). Human umbilical mesenchymal …

Background Discovering novel compounds with higher activities is a key aim of natural
products research. Gardenia jasminoides Ellis is a herb with anti-inflammatory properties …

For over a half-century the anti-malarial drug chloroquine (CQ) has been used as a
therapeutic agent, alone or in combination, to treat autoimmune diseases. However, neither …

Sinomenine (SIN) has long been used as a therapeutic agent of rheumatoid arthritis (RA) in
China. However, the discrepancy between low oral bioavailability and higher minimal …