NK cells are never alone: crosstalk and communication in tumour microenvironments

Y Zhou, L Cheng, L Liu, X Li - Molecular Cancer, 2023 - Springer
Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour
microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) …

Fundamental mechanisms of immune checkpoint blockade therapy

SC Wei, CR Duffy, JP Allison - Cancer discovery, 2018 - aacrjournals.org
Immune checkpoint blockade is able to induce durable responses across multiple types of
cancer, which has enabled the oncology community to begin to envision potentially curative …

Aging of the immune system: focus on natural killer cells phenotype and functions

A Brauning, M Rae, G Zhu, E Fulton, TD Admasu… - Cells, 2022 - mdpi.com
Aging is the greatest risk factor for nearly all major chronic diseases, including
cardiovascular diseases, cancer, Alzheimer's and other neurodegenerative diseases of …

Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors

J Ni, M Miller, A Stojanovic, N Garbi… - Journal of Experimental …, 2012 - rupress.org
Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors |
Journal of Experimental Medicine | Rockefeller University Press Skip to Main Content …

The role of TNF superfamily members in T-cell function and diseases

M Croft - Nature Reviews Immunology, 2009 - nature.com
Interactions that occur between several tumour necrosis factor (TNF)–TNF receptors that are
expressed by T cells and various other immune and non-immune cell types are central to T …

The significance of OX40 and OX40L to T‐cell biology and immune disease

M Croft, T So, W Duan, P Soroosh - Immunological reviews, 2009 - Wiley Online Library
OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis
factor receptor/tumor necrosis factor superfamily and are expressed on activated CD4+ and …

Formation and function of the lytic NK-cell immunological synapse

JS Orange - Nature Reviews Immunology, 2008 - nature.com
The natural killer (NK)-cell immunological synapse is the dynamic interface formed between
an NK cell and its target cell. Formation of the NK-cell immunological synapse involves …

Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell–mediated deletion

D Peppa, US Gill, G Reynolds, NJW Easom… - Journal of Experimental …, 2013 - rupress.org
Antiviral T cell responses in hepatotropic viral infections such as hepatitis B virus (HBV) are
profoundly diminished and prone to apoptotic deletion. In this study, we investigate whether …

Control of immunity by the TNFR-related molecule OX40 (CD134)

M Croft - Annual review of immunology, 2009 - annualreviews.org
TNFR/TNF superfamily members can control diverse aspects of immune function. Research
over the past 10 years has shown that one of the most important and prominent interactions …

Recognition and regulation of T cells by NK cells

K Pallmer, A Oxenius - Frontiers in immunology, 2016 - frontiersin.org
Regulation of T cell responses by innate lymphoid cells (ILCs) is increasingly documented
and studied. Direct or indirect crosstalk between ILCs and T cells early during and after T …