Polyvalent interactions in biological systems: implications for design and use of multivalent ligands and inhibitors

M Mammen, SK Choi… - Angewandte Chemie …, 1998 - Wiley Online Library
Found throughout biology, polyvalent interactions are characterized by the simultaneous
binding of multiple ligands on one biological entity to multiple receptors on another (top part …

Dendrimers in biomedical applications—reflections on the field

S Svenson, DA Tomalia - Advanced drug delivery reviews, 2012 - Elsevier
The formation of particulate systems with well-defined sizes and shapes is of eminent
interest in certain medical applications such as drug delivery, gene transfection, and …

Polyvalente Wechselwirkungen in biologischen Systemen: Auswirkungen auf das Design und die Verwendung multivalenter Liganden und Inhibitoren

M Mammen, SK Choi, GM Whitesides - Angewandte Chemie, 1998 - Wiley Online Library
Überall in der Biologie kommen polyvalente Wechselwirkungen vor. Sie zeichnen sich
durch die gleichzeitige Bindung mehrerer Liganden einer biologischen Einheit an mehrere …

The cluster glycoside effect

JJ Lundquist, EJ Toone - Chemical reviews, 2002 - ACS Publications
Myriad biological communication events achieve the requisite level of specificity by
exploiting the rich structural and functional diversity of glycoconjugates. Although a wide …

Glycopolymer nanobiotechnology

Y Miura, Y Hoshino, H Seto - Chemical reviews, 2016 - ACS Publications
Molecular recognition plays an important role in living systems. 1, 2 Representative
molecular recognitions in living organisms are saccharide− protein, protein− protein, and …

Polymer therapeutics: concepts and applications

R Haag, F Kratz - Angewandte Chemie International Edition, 2006 - Wiley Online Library
Polymer therapeutics encompass polymer–protein conjugates, drug–polymer conjugates,
and supramolecular drug‐delivery systems. Numerous polymer–protein conjugates with …

Functional dendrimers, hyperbranched and star polymers

K Inoue - Progress in polymer science, 2000 - Elsevier
Over the past decade, a number of excellent reviews on hyperbranched polymers and
dendrimers have been published covering the topics from details to highlights and …

Modular synthesis of amphiphilic Janus glycodendrimers and their self-assembly into glycodendrimersomes and other complex architectures with bioactivity to …

V Percec, P Leowanawat, HJ Sun… - Journal of the …, 2013 - ACS Publications
The modular synthesis of 7 libraries containing 51 self-assembling amphiphilic Janus
dendrimers with the monosaccharides d-mannose and d-galactose and the disaccharide d …

Dendrimers: from design to application—a progress report

M Fischer, F Vögtle - Angewandte Chemie International Edition, 1999 - Wiley Online Library
A unique combination of a clearly defined particle structure and a very highly functionalized
surface is offered by the topical dendrimers. Many groups work on this unusual molecular …

Dendritic polymers in biomedical applications: from potential to clinical use in diagnostics and therapy

SE Stiriba, H Frey, R Haag - Angewandte Chemie International …, 2002 - Wiley Online Library
Dendrimers are characterized by a combination of high end‐group functionality and a
compact, precisely defined molecular structure. These characteristics can be used in …