Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Viruses manipulate cellular metabolism and macromolecule recycling processes like
autophagy. Dysregulated metabolism might lead to excessive inflammatory and …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Translational control of mRNAs during gene expression allows cells to promptly and
dynamically adapt to a variety of stimuli, including in neoplasia in response to aberrant …

Polyamine synthesis represents one of the most profound metabolic changes during T cell
activation, but the biological implications of this are scarcely known. Here, we show that …

Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …

Spermidine (SPD) delays age-related pathologies in various organisms. SPD
supplementation overcame the impaired immunotherapy against tumors in aged mice by …

Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis
and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here …

Immunometabolism has emerged as a major mechanism central to adaptive and innate
immune regulation. From early observations that inflammatory cytokines were induced in …