The vascular endothelium has several important functions, including hemostasis. The
homeostasis of hemostasis is based on a fine balance between procoagulant and …

Tissue factor pathway inhibitor (TFPI) is an alternatively spliced anticoagulant protein that
primarily dampens the initiation phase of coagulation before thrombin is generated. As such …

Hemochorial placentation is characterized by the development of trophoblast cells
specialized to interact with the uterine vascular bed. We utilized trophoblast stem (TS) cell …

Bleeding and thrombosis are known as common complications of polycythemia for a long
time. However, the role of coagulation system in erythropoiesis is unclear. Here, we discover …

Increased cerebrovascular amyloid-β (Aβ) deposition represents the main pathogenic
mechanisms characterizing Alzheimer's disease (AD) and cerebral amyloid angiopathy …

Wound healing is a complex physiological process in which the damaged or injured tissue is
replaced or regenerated by new cells or existing cells respectively in their synthesized and …

Blood coagulation is a vital physiological process involving a complex network of
biochemical reactions, which converge to form a blood clot that repairs vascular injury. This …

Neurological diseases (ND), including neurodegenerative diseases (NDD) and psychiatric
disorders (PD), present a significant public health challenge, ranking third in Europe for …

The Fourth Maastricht Consensus Conference on Thrombosis included the following
themes. Theme 1: The “coagulome” as a critical driver of cardiovascular disease. Blood …

Background Tissue factor pathway inhibitor (TFPI) is an essential regulator of coagulation,
limiting thrombin generation and preventing thrombosis. In humans and mice, TFPIα is the …