Primary open-angle glaucoma
RN Weinreb, CKS Leung, JG Crowston… - Nature reviews Disease …, 2016 - nature.com
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …
Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability
Retinal ganglion cells (RGCs) are specialized projection neurons that relay an immense
amount of visual information from the retina to the brain. RGC signal inputs are collected by …
amount of visual information from the retina to the brain. RGC signal inputs are collected by …
Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury
Dendrite pathology and synapse disassembly are critical features of chronic
neurodegenerative diseases. In spite of this, the capacity of injured neurons to regenerate …
neurodegenerative diseases. In spite of this, the capacity of injured neurons to regenerate …
The coma in glaucoma: Retinal ganglion cell dysfunction and recovery
Retinal ganglion cell (RGC) degeneration causes vision loss in patients with glaucoma, and
this has been generally considered to be irreversible due to RGC death. We question this …
this has been generally considered to be irreversible due to RGC death. We question this …
Integrating macular ganglion cell inner plexiform layer and parapapillary retinal nerve fiber layer measurements to detect glaucoma progression
HW Hou, C Lin, CKS Leung - Ophthalmology, 2018 - Elsevier
Purpose To investigate the temporal relationship among progressive macular ganglion cell
inner plexiform layer (GCIPL) thinning, progressive parapapillary retinal nerve fiber layer …
inner plexiform layer (GCIPL) thinning, progressive parapapillary retinal nerve fiber layer …
Age and intraocular pressure in murine experimental glaucoma
J Di Pierdomenico, DCM Henderson… - Progress in Retinal and …, 2022 - Elsevier
Age and intraocular pressure (IOP) are the two most important risk factors for the
development and progression of open-angle glaucoma. While IOP is commonly considered …
development and progression of open-angle glaucoma. While IOP is commonly considered …
Retinal ganglion cell dendrite pathology and synapse loss: implications for glaucoma
J Agostinone, A Di Polo - Progress in brain research, 2015 - Elsevier
Dendrites are exquisitely specialized cellular compartments that critically influence how
neurons collect and process information. Retinal ganglion cell (RGC) dendrites receive …
neurons collect and process information. Retinal ganglion cell (RGC) dendrites receive …
Assessment of retinal ganglion cell damage in glaucomatous optic neuropathy: axon transport, injury and soma loss
AC Nuschke, SR Farrell, JM Levesque… - Experimental eye …, 2015 - Elsevier
Glaucoma is a disease characterized by progressive axonal pathology and death of retinal
ganglion cells (RGCs), which causes structural changes in the optic nerve head and …
ganglion cells (RGCs), which causes structural changes in the optic nerve head and …
Green tea catechins are potent anti-oxidants that ameliorate sodium iodate-induced retinal degeneration in rats
Y Yang, YJ Qin, YWY Yip, KP Chan, KO Chu… - Scientific reports, 2016 - nature.com
Green tea extracts exhibit anti-oxidative and anti-inflammatory actions in different disease
conditions. We hypothesized that green tea extract and its catechin constituents ameliorate …
conditions. We hypothesized that green tea extract and its catechin constituents ameliorate …
Identifying new drugs and targets to treat rapidly elevated intraocular pressure for angle closure and secondary glaucomas to curb visual impairment and prevent …
NA Sharif - Experimental eye research, 2023 - Elsevier
A multitude of pharmacological compounds have been shown to lower and control
intraocular pressure (IOP) in numerous species of animals and human subjects after topical …
intraocular pressure (IOP) in numerous species of animals and human subjects after topical …