Primary open-angle glaucoma

RN Weinreb, CKS Leung, JG Crowston… - Nature reviews Disease …, 2016 - nature.com
Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …

Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability

DY Yu, SJ Cringle, C Balaratnasingam… - Progress in retinal and …, 2013 - Elsevier
Retinal ganglion cells (RGCs) are specialized projection neurons that relay an immense
amount of visual information from the retina to the brain. RGC signal inputs are collected by …

Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury

J Agostinone, L Alarcon-Martinez, C Gamlin, WQ Yu… - Brain, 2018 - academic.oup.com
Dendrite pathology and synapse disassembly are critical features of chronic
neurodegenerative diseases. In spite of this, the capacity of injured neurons to regenerate …

The coma in glaucoma: Retinal ganglion cell dysfunction and recovery

LE Fry, E Fahy, V Chrysostomou, F Hui, J Tang… - Progress in retinal and …, 2018 - Elsevier
Retinal ganglion cell (RGC) degeneration causes vision loss in patients with glaucoma, and
this has been generally considered to be irreversible due to RGC death. We question this …

Integrating macular ganglion cell inner plexiform layer and parapapillary retinal nerve fiber layer measurements to detect glaucoma progression

HW Hou, C Lin, CKS Leung - Ophthalmology, 2018 - Elsevier
Purpose To investigate the temporal relationship among progressive macular ganglion cell
inner plexiform layer (GCIPL) thinning, progressive parapapillary retinal nerve fiber layer …

Age and intraocular pressure in murine experimental glaucoma

J Di Pierdomenico, DCM Henderson… - Progress in Retinal and …, 2022 - Elsevier
Age and intraocular pressure (IOP) are the two most important risk factors for the
development and progression of open-angle glaucoma. While IOP is commonly considered …

Retinal ganglion cell dendrite pathology and synapse loss: implications for glaucoma

J Agostinone, A Di Polo - Progress in brain research, 2015 - Elsevier
Dendrites are exquisitely specialized cellular compartments that critically influence how
neurons collect and process information. Retinal ganglion cell (RGC) dendrites receive …

Assessment of retinal ganglion cell damage in glaucomatous optic neuropathy: axon transport, injury and soma loss

AC Nuschke, SR Farrell, JM Levesque… - Experimental eye …, 2015 - Elsevier
Glaucoma is a disease characterized by progressive axonal pathology and death of retinal
ganglion cells (RGCs), which causes structural changes in the optic nerve head and …

Green tea catechins are potent anti-oxidants that ameliorate sodium iodate-induced retinal degeneration in rats

Y Yang, YJ Qin, YWY Yip, KP Chan, KO Chu… - Scientific reports, 2016 - nature.com
Green tea extracts exhibit anti-oxidative and anti-inflammatory actions in different disease
conditions. We hypothesized that green tea extract and its catechin constituents ameliorate …

Identifying new drugs and targets to treat rapidly elevated intraocular pressure for angle closure and secondary glaucomas to curb visual impairment and prevent …

NA Sharif - Experimental eye research, 2023 - Elsevier
A multitude of pharmacological compounds have been shown to lower and control
intraocular pressure (IOP) in numerous species of animals and human subjects after topical …