Chiral spirocyclopropyl β-lactams are common motifs in bioactive compounds and
pharmaceuticals. Here we disclose a diastereoselective and enantioselective …

Abstract β-Lactam compounds hold a prominent position in modern organic synthesis,
garnering significant attention due to their role as “privileged pharmacological structures” …

Abstract β-Lactams have long been a cornerstone in the treatment of various bacterial
infections, largely due to their unique structure–activity relationship with pathogenic bacteria …

The preparation of the β-lactam motif containing both C–Br and N–O bonds as functional
handles remains an unmet synthetic challenge. Described herein is a novel and highly …

The reactivity of alkyl (aryl) phosphinic chlorides and imines was investigated in the
presence of a base. The results indicated that allyl/benzyl (aryl) phosphinic chlorides gave …

In this study, we designed and synthesized a series of β-lactam compounds bearing 14-
phenyl-14H-dibenzo [a, j] xanthene moiety attached to the N-1 position of the β-lactam ring …

Herein, we unveil the utility of bis (5-phenylcarbamoylpentyl) diselenide 2 for obtaining
unique seleno-ester viz ethyl 2-(5-(phenylcarbamoyl) pentylselenyl) ethanoate 3 and further …

Abstract The Staudinger ketene-imine [2+ 2] cycloaddition provides an efficient strategy to
produce polysubstituted β-lactam rings, resulting in two pairs of enantiomers with cis/trans …

Spirocyclic β-lactams are a family of natural and synthetic chemicals with different biological
activity, including antibacterial properties and interaction with critical physiological targets …

The review covers work published in the calendar year 2022. The synthesis and reactivity of
four-membered heteroatom-containing cycles are reviewed. New developments in the …