Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

Discoveries in fruit flies have greatly contributed to our understanding of neuroscience. The
use of an unparalleled wealth of tools, many of which originated between 1910–1960, has …

Extensive research has yielded crucial insights into the mechanism of neurotransmitter
release, and working models for the functions of key proteins involved in release. The …

Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

Synaptic vesicle recycling is one of the best‐studied cellular pathways. Many of the proteins
involved are known, and their interactions are becoming increasingly clear. However, as for …

This review summarizes current knowledge of synaptic proteins that are central to synaptic
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …

Chemical synapses are sites of contact and information transfer between a neuron and its
partner cell. Each synapse is a specialized junction, where the presynaptic cell assembles …

Intracellular vesicle trafficking is the fundamental process to maintain the homeostasis of
membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from …

Synaptic vesicle (SV) exocytosis is mediated by SNARE proteins. Reconstituted SNAREs
are constitutively active, so a major focus has been to identify fusion clamps that regulate …

Membrane fusion during exocytosis is mediated by assemblies of SNARE (soluble NSF-
attachment protein receptor) and SM (Sec1/Munc18-like) proteins. The SNARE/SM proteins …