Delirium and dementia are two frequent causes of cognitive impairment among older adults
and have a distinct, complex and interconnected relationship. Delirium is an acute …

Injury is a key driver of inflammation, a critical yet necessary response involving several
mediators that is aimed at restoring tissue homeostasis. Inflammation in the central nervous …

Update of the European Society of Anaesthesiology and Intens... : European Journal of
Anaesthesiology | EJA Update of the European Society of Anaesthesiology and Intensive Care …

Chronic heart failure (CHF) is the final outcome of many cardiovascular diseases, and is a
severe health issue faced by the elderly population. Mixed lineage kinase 3 (MLK3), a …

Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of
general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence …

Background Postoperative cognitive dysfunction (POCD) is a very common complication that
might increase the morbidity and mortality of elderly patients after surgery. However, the …

Background Microglial polarization toward pro-inflammatory M1 phenotype are major
contributors to the development of perioperative neurocognitive disorders (PNDs). Metabolic …

Objective The present work evaluates the relationship between postoperative immune and
neurovascular changes and the pathogenesis of surgery‐induced delirium superimposed …

With the worldwide increase in life span, surgical patients are becoming older and have a
greater propensity for postoperative cognitive impairment, either new onset or through …

Perioperative neurocognitive disorder (PND) is a common complication in surgical patients.
While many interventions to prevent PND have been studied, the availability of treatment …