Clathrin-mediated endocytosis (CME) is the major endocytic pathway in mammalian cells. It
is responsible for the uptake of transmembrane receptors and transporters, for remodeling …

In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a
protein is determined by its amino acid sequence. This work laid the foundation for the …

The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975
was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered …

Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane,
where its assembly into cage-like lattices underlies the clathrin-coated pits of classical …

Curved membranes are an essential feature of dynamic cellular structures, including
endocytic pits, filopodia protrusions and most organelles,. It has been proposed that …

Membrane curvature is no longer seen as a passive consequence of cellular activity but an
active means to create membrane domains and to organize centres for membrane …

Numerous endocytic accessory proteins (EAPs) mediate assembly and maturation of
clathrin-coated pits (CCPs) into cargo-containing vesicles. Analysis of EAP function through …

Ubiquitin-binding domains (UBDs) are a collection of modular protein domains that non-
covalently bind to ubiquitin. These recently discovered motifs interpret and transmit …

The critical initiation phase of clathrin-mediated endocytosis (CME) determines where and
when endocytosis occurs. Heterotetrameric adaptor protein 2 (AP2) complexes, which …

Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …