Diversity of AMPA receptor ligands: Chemotypes, binding modes, mechanisms of action, and therapeutic effects
EA Golubeva, MI Lavrov, EV Radchenko, VA Palyulin - Biomolecules, 2022 - mdpi.com
L-Glutamic acid is the main excitatory neurotransmitter in the central nervous system (CNS).
Its associated receptors localized on neuronal and non-neuronal cells mediate rapid …
Its associated receptors localized on neuronal and non-neuronal cells mediate rapid …
Deciphering the biophysical properties of ion channel gating pores by coumarin–benzodiazepine hybrid derivatives: selective AMPA receptor antagonists
In the 1980s, the identification of specific pharmacological antagonists played a crucial role
in enhancing our comprehension of the physiological mechanisms associated with α-amino …
in enhancing our comprehension of the physiological mechanisms associated with α-amino …
Assessing Artemisia arborescens essential oil compositions, antimicrobial, cytotoxic, anti-inflammatory, and neuroprotective effects gathered from two geographic …
Artemisia arborescens essential oil (EO), collected from two Palestinian regions, Bethlehem
and Jenin, were extracted by hydro-distillation and examined for their chemical …
and Jenin, were extracted by hydro-distillation and examined for their chemical …
Curcumin, resveratrol and cannabidiol as natural key prototypes in drug design for neuroprotective agents
FPD Viegas, VS Gontijo… - Current …, 2022 - benthamdirect.com
Nowadays, neurodegenerative diseases (NDs), such as Parkinson's disease (PD),
Alzheimer's disease (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis …
Alzheimer's disease (AD), Huntington's disease (HD), and amyotrophic lateral sclerosis …
Multi-biological activity assessment and phytochemical characterization of an aqueous extract of the Cymbopogon citratus grown in Palestine
Background Plants have historically been a rich source of medicinal compounds, with many
modern pharmaceuticals derived from botanical origins. In contemporary healthcare, there is …
modern pharmaceuticals derived from botanical origins. In contemporary healthcare, there is …
Inula viscosa (L.) Greuter, phytochemical composition, antioxidant, total phenolic content, total flavonoids content and neuroprotective effects
Abstract Introduction Inula viscosa (L.) Greuter (DV) has been utilized in folk medicine due to
its anti-inflammatory, diuretic, antiseptic, and antiphlogistic properties. Numerous studies …
its anti-inflammatory, diuretic, antiseptic, and antiphlogistic properties. Numerous studies …
Ortho versus meta chlorophenyl-2, 3-benzodiazepine analogues: synthesis, molecular modeling, and biological activity as AMPAR antagonists
2, 3-Benzodiazepine compounds are an important family of α-amino-3-hydroxy-5-methyl-4-
isoxazolepropionic acid receptor (AMPAR) antagonists that act in a noncompetitive manner …
isoxazolepropionic acid receptor (AMPAR) antagonists that act in a noncompetitive manner …
The AMPA receptor biophysical gating properties and binding site: Focus on novel curcumin-based diazepines as non-competitive antagonists
Introduction Investigating the binding site of six novel curcumin-based diazepine
compounds as a non-competitive antagonist on ionotropic, AMPA-type glutamate receptors …
compounds as a non-competitive antagonist on ionotropic, AMPA-type glutamate receptors …
Targeting the kinetics mechanism of AMPA receptor inhibition by 2-oxo-3H-benzoxazole derivatives
Ionotropic glutamate receptors are ligand-gated ion channels found in most excitatory
synapses in the brain that allow for rapid information transfer. Due to their quick excitatory …
synapses in the brain that allow for rapid information transfer. Due to their quick excitatory …
The effect of novel negative allosteric 2, 3-benzodiazepine on glutamate AMPA receptor and their cytotoxicity
Benzodiazepine (2, 3-BDZ) compounds represent a group of structurally varied antagonists
of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor. AMPA receptor …
of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor. AMPA receptor …