Molecular aspects of fructose metabolism and metabolic disease

MA Herman, MJ Birnbaum - Cell metabolism, 2021 - cell.com
Excessive sugar consumption is increasingly considered as a contributor to the emerging
epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet …

Overview of non-alcoholic fatty liver disease (NAFLD) and the role of sugary food consumption and other dietary components in its development

P Vancells Lujan, E Vinas Esmel… - Nutrients, 2021 - mdpi.com
NAFLD is the world's most common chronic liver disease, and its increasing prevalence
parallels the global rise in diabetes and obesity. It is characterised by fat accumulation in the …

Treatment of NAFLD with diet, physical activity and exercise

M Romero-Gómez, S Zelber-Sagi, M Trenell - Journal of hepatology, 2017 - Elsevier
Lifestyle intervention can be effective when treating non-alcoholic fatty liver diseases
(NAFLD) patients. Weight loss decreases cardiovascular and diabetes risk and can also …

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

E Buzzetti, M Pinzani, EA Tsochatzis - Metabolism, 2016 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing
challenge in terms of prevention and treatment. Despite its high prevalence, only a small …

The role of the gut microbiota in NAFLD

C Leung, L Rivera, JB Furness… - … reviews Gastroenterology & …, 2016 - nature.com
NAFLD is now the most common cause of liver disease in Western countries. This Review
explores the links between NAFLD, the metabolic syndrome, dysbiosis, poor diet and gut …

[HTML][HTML] Dietary fructose and the metabolic syndrome

MR Taskinen, CJ Packard, J Borén - Nutrients, 2019 - mdpi.com
Consumption of fructose, the sweetest of all naturally occurring carbohydrates, has
increased dramatically in the last 40 years and is today commonly used commercially in soft …

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

S Softic, MK Gupta, GX Wang, S Fujisaka… - The Journal of clinical …, 2017 - jci.org
Overconsumption of high-fat diet (HFD) and sugar-sweetened beverages are risk factors for
develo** obesity, insulin resistance, and fatty liver disease. Here we have dissected …

Dietary sugars alter hepatic fatty acid oxidation via transcriptional and post-translational modifications of mitochondrial proteins

S Softic, JG Meyer, GX Wang, MK Gupta, TM Batista… - Cell metabolism, 2019 - cell.com
Dietary sugars, fructose and glucose, promote hepatic de novo lipogenesis and modify the
effects of a high-fat diet (HFD) on the development of insulin resistance. Here, we show that …

[HTML][HTML] Current concepts, opportunities, and challenges of gut microbiome-based personalized medicine in nonalcoholic fatty liver disease

SR Sharpton, B Schnabl, R Knight, R Loomba - Cell metabolism, 2021 - cell.com
Nonalcoholic fatty liver disease (NALFD) is now a leading cause of chronic liver disease
worldwide, in part, as a consequence of rapidly rising levels of obesity and metabolic …

[HTML][HTML] Adherence to mediterranean diet and NAFLD in patients with metabolic syndrome: the FLIPAN study

S Montemayor, CM Mascaró, L Ugarriza, M Casares… - Nutrients, 2022 - mdpi.com
Unhealthy diet is an important factor in the progression of non-alcoholic fatty liver disease
(NAFLD). Previous studies showed the benefits of a Mediterranean diet (MedDiet) on …