Rapid review of suspected adverse drug events due to remdesivir in the WHO database; findings and implications
Objectives: Remdesivir has shown promise in the management of patients with COVID-19
although recent studies have shown concerns with its effectiveness in practice. Despite this …
although recent studies have shown concerns with its effectiveness in practice. Despite this …
Long-term treatment with clozapine and other antipsychotic drugs and the risk of haematological malignancies in people with schizophrenia: a nationwide case …
Background Clozapine is the most efficacious treatment for schizophrenia and is associated
with lower overall mortality than are other antipsychotic drugs, despite the risk of …
with lower overall mortality than are other antipsychotic drugs, despite the risk of …
Safety of antipsychotic drugs: a systematic review of disproportionality analysis studies
Antipsychotic drugs are commonly prescribed, mainly for the treatment of schizophrenia and
other psychotic disorders. Disproportionality analysis of pharmacovigilance data from …
other psychotic disorders. Disproportionality analysis of pharmacovigilance data from …
Association between disease-modifying therapies prescribed to persons with multiple sclerosis and cancer: a WHO pharmacovigilance database analysis
C Dolladille, B Chrétien, L Peyro-Saint-Paul… - …, 2021 - Springer
The risk of cancer associated with persons with multiple sclerosis (pwMS) prescribed with
disease modifying therapies (DMTs) is not well established. This observational, cross …
disease modifying therapies (DMTs) is not well established. This observational, cross …
Neutrophil Myeloperoxidase-Mediated N-Demethylation of Quetiapine Leads to N-Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite
MH Rashid, D Babu, N Tran, B Reiz… - Chemical Research in …, 2022 - ACS Publications
The atypical antipsychotic drugs, quetiapine and clozapine, are associated with idiosyncratic
drug reactions (such as agranulocytosis or neutropenia) that are thought to involve reactive …
drug reactions (such as agranulocytosis or neutropenia) that are thought to involve reactive …
Disproportionality analysis in VigiBase as a drug repositioning method for the discovery of potentially useful drugs in Alzheimer's disease
B Chrétien, JP Jourdan, A Davis… - British Journal of …, 2021 - Wiley Online Library
Aims Drug repositioning aims to propose new indications for marketed drugs. Although
several methods exist, the utility of pharmacovigilance databases for this purpose is unclear …
several methods exist, the utility of pharmacovigilance databases for this purpose is unclear …
Rare but elevated incidence of hematological malignancy after clozapine use in schizophrenia: A population cohort study
Background Clozapine is widely regarded as a highly efficacious psychotropic drug that is
largely underused worldwide. Recent disproportionality analyses and nationwide case …
largely underused worldwide. Recent disproportionality analyses and nationwide case …
Rhabdomyolysis with Co-Administration of Statins and Antiplatelet Therapies—Analysis of the WHO Pharmacovigilance Database
Purpose While statins and antiplatelet therapies are largely prescribed together worldwide,
limited information is available on the safety of their association regarding rhabdomyolysis …
limited information is available on the safety of their association regarding rhabdomyolysis …
Small-interfering RNA targeting proprotein convertase subtilisin/kexin type 9 might promote fatty liver disease and hepatocellular carcinoma through upregulation of …
FS Fan - Tumor Biology, 2023 - content.iospress.com
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein (LDL)
receptor and fatty acid translocase CD36, inducing lysosomal degradation of these two …
receptor and fatty acid translocase CD36, inducing lysosomal degradation of these two …
Association between road traffic accidents and drugs belonging to the antiseizure medications class: A pharmacovigilance analysis in VigiBase
B Chrétien, S Nguyen, C Dolladille… - British journal of …, 2023 - Wiley Online Library
Aims Due to their central mechanism of action, antiseizure medications (ASMs) could lead to
adverse effects likely to impair driving skills. Their extended use to neuropsychiatric …
adverse effects likely to impair driving skills. Their extended use to neuropsychiatric …