Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

This review provides a comprehensive landscape of HGF/c-MET (hepatocyte growth factor
(HGF)/mesenchymal–epithelial transition factor (c-MET)) signaling pathway in cancers. First …

The MET oncogene encodes an unconventional receptor tyrosine kinase with pleiotropic
functions: it initiates and sustains neoplastic transformation when genetically altered …

Uncontrolled cell survival, growth, angiogenesis and metastasis are essential hallmarks of
cancer. Genetic and biochemical data have demonstrated that the growth and motility factor …

The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …

c-MET is a receptor tyrosine kinase that, after binding with its ligand, hepatocyte growth
factor, activates a wide range of different cellular signaling pathways, including those …

Metastasis resistant to therapy is the major cause of death from cancer. Despite almost 200
years of study, the process of tumor metastasis remains controversial. Stephen Paget initially …

The MET tyrosine kinase receptor (also known as the HGF receptor) promotes tissue
remodelling, which underlies developmental morphogenesis, wound repair, organ …

Purpose To further understand the molecular pathogenesis of pulmonary sarcomatoid
carcinoma (PSC) and develop new therapeutic strategies in this treatment-refractory …

Without epithelial–mesenchymal transitions, in which polarized epithelial cells are converted
into motile cells, multicellular organisms would be incapable of getting past the blastula …