The global spread of drug resistance in bacteria requires new potent and safe antimicrobial
agents. Compounds containing the 1, 2, 4-triazole ring in their structure are characterised by …

Bacterial infections have attracted the attention of researchers in recent decades, especially
due to the special problems they have faced, such as their increasing diversity and …

Abstract Since its discovery 1, 2, 4-triazole ring has emerged as a prominent heterocyclic
scaffold in medicinal chemistry. It possesses a wide spectrum of biological activities such as …

In this research, a series of novel hybrid structures of dimethylpyridine-1, 2, 4-triazole Schiff
bases were designed, synthesized, and evaluated for their in vitro cytotoxic potency on …

In this study, a series of 1, 3, 4-oxadiazole derivatives (5a-s, 10a-s, and 16a-d) were
designed and synthesized using maximal electroshock (MES) and subcutaneous …

The lack of effective therapies for epileptic patients and the potentially harmful
consequences of untreated seizure incidents have made epileptic disorders in humans a …

There are numerous studies supporting the contribution of oxidative stress to the
pathogenesis of epilepsy. Prolonged oxidative stress is associated with the overexpression …

The development of drug-resistant bacteria is currently one of the major challenges in
medicine. Therefore, the discovery of novel lead structures for the design of antibacterial …

Epilepsy is one of the most common neurological disorders worldwide and it requires a long-
term or life-long treatment. Current standard treatment includes the use of antiepileptic …

The main aim of the current project was to investigate the effect of the linker size in 4-alkyl-5-
aryl-1, 2, 4-triazole-3-thione derivatives, known as a group of antiepileptic drug candidates …