Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula

L Zhao, H Zhang, N Li, J Chen, H Xu, Y Wang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …

Deep learning for drug repurposing: Methods, databases, and applications

X Pan, X Lin, D Cao, X Zeng, PS Yu… - Wiley …, 2022 - Wiley Online Library
Drug development is time‐consuming and expensive. Repurposing existing drugs for new
therapies is an attractive solution that accelerates drug development at reduced …

[HTML][HTML] Spatial epigenome–transcriptome co-profiling of mammalian tissues

D Zhang, Y Deng, P Kukanja, E Agirre, M Bartosovic… - Nature, 2023 - nature.com
Emerging spatial technologies, including spatial transcriptomics and spatial epigenomics,
are becoming powerful tools for profiling of cellular states in the tissue context,,,–. However …

AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences

M Varadi, D Bertoni, P Magana, U Paramval… - Nucleic acids …, 2024 - academic.oup.com
Abstract The AlphaFold Database Protein Structure Database (AlphaFold DB,
https://alphafold. ebi. ac. uk) has significantly impacted structural biology by amassing over …

[HTML][HTML] Glioblastoma hijacks neuronal mechanisms for brain invasion

V Venkataramani, Y Yang, MC Schubert, E Reyhan… - Cell, 2022 - cell.com
Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma
cells forms a functional and therapy-resistant tumor cell network interconnected by tumor …

[HTML][HTML] Spatial profiling of chromatin accessibility in mouse and human tissues

Y Deng, M Bartosovic, S Ma, D Zhang, P Kukanja… - Nature, 2022 - nature.com
Cellular function in tissue is dependent on the local environment, requiring new methods for
spatial map** of biomolecules and cells in the tissue context. The emergence of spatial …

Spatial-CUT&Tag: spatially resolved chromatin modification profiling at the cellular level

Y Deng, M Bartosovic, P Kukanja, D Zhang, Y Liu, G Su… - Science, 2022 - science.org
Spatial omics emerged as a new frontier of biological and biomedical research. Here, we
present spatial-CUT&Tag for spatially resolved genome-wide profiling of histone …

A comprehensive human embryo reference tool using single-cell RNA-sequencing data

C Zhao, A Plaza Reyes, JP Schell, J Weltner… - Nature …, 2024 - nature.com
Stem cell-based embryo models offer unprecedented experimental tools for studying early
human development. The usefulness of embryo models hinges on their molecular, cellular …

A human cell atlas of fetal gene expression

J Cao, DR O'day, HA Pliner, PD Kingsley, M Deng… - Science, 2020 - science.org
INTRODUCTION A reference atlas of human cell types is a major goal for the field. Here, we
set out to generate single-cell atlases of both gene expression (this study) and chromatin …

The genecards suite

M Safran, N Rosen, M Twik, R BarShir, TI Stein… - Practical guide to life …, 2021 - Springer
The GeneCards® database of human genes was launched in 1997 and has expanded
since then to encompass gene-centric, disease-centric, and pathway-centric entities and …