Metal-based nanoenhancers for future radiotherapy: radiosensitizing and synergistic effects on tumor cells

Y Liu, P Zhang, F Li, X **, J Li, W Chen, Q Li - Theranostics, 2018 - pmc.ncbi.nlm.nih.gov
Radiotherapy is one of the major therapeutic strategies for cancer treatment. In the past
decade, there has been growing interest in using high Z (atomic number) elements …

Nanoparticle radio-enhancement: principles, progress and application to cancer treatment

Z Kuncic, S Lacombe - Physics in Medicine & Biology, 2018 - iopscience.iop.org
Enhancement of radiation effects by high-atomic number nanoparticles (NPs) has been
increasingly studied for its potential to improve radiotherapeutic efficacy. The underlying …

In situ imaging of metals in cells and tissues

R McRae, P Bagchi, S Sumalekshmy… - Chemical …, 2009 - ACS Publications
Approximately one third of the human proteome contains metal cations, either in the form of
cofactors with catalytic functions or as structural support elements. 1, 2 To guarantee a …

Medical applications of synchrotron radiation

P Suortti, W Thomlinson - Physics in Medicine & Biology, 2003 - iopscience.iop.org
The medical imaging and therapeutic technologies that are based on the use of radiation
are reviewed briefly, with special emphasis on the recent developments of synchrotron …

Characterization and some physicochemical aspects of pathological microcalcifications

D Bazin, M Daudon, C Combes, C Rey - Chemical Reviews, 2012 - ACS Publications
Several major diseases, such as cancer and cardiovascular abnormalities, may be linked to
pathological deposition of minerals or organic compounds in various tissues. 1− 3 Thus, the …

pH-sensitive Pt nanocluster assembly overcomes cisplatin resistance and heterogeneous stemness of hepatocellular carcinoma

H **a, F Li, X Hu, W Park, S Wang, Y Jang… - ACS central …, 2016 - ACS Publications
Response rates to conventional chemotherapeutics remain unsatisfactory for hepatocellular
carcinoma (HCC) due to the high rates of chemoresistance and recurrence. Tumor-initiating …

Characterization of the theorectical radiation dose enhancement from nanoparticles

JC Roeske, L Nunez, M Hoggarth… - … in cancer research …, 2007 - journals.sagepub.com
Recently, nanoparticles have been considered as a method of providing radiation dose
enhancement in tumors. In order to quantify this affect, a dose enhancement factor (DEF) is …

Cure of Fisher Rats Bearing Radioresistant F98 Glioma Treated with cis-Platinum and Irradiated with Monochromatic Synchrotron X-Rays

MC Biston, A Joubert, JF Adam, H Elleaume… - Cancer …, 2004 - aacrjournals.org
High-grade gliomas are usually of poor prognosis, and conventional radiotherapy, even
combined with chemotherapy, still fails to improve the survival of patients. Here, we propose …

Synchrotron radiation-based experimental determination of the optimal energy for cell radiotoxicity enhancement following photoelectric effect on stable iodinated …

S Corde, A Joubert, JF Adam, AM Charvet… - British journal of …, 2004 - nature.com
This study was designed to experimentally evaluate the optimal X-ray energy for increasing
the radiation energy absorbed in tumours loaded with iodinated compounds, using the …

Preserving elemental content in adherent mammalian cells for analysis by synchrotron‐based x‐ray fluorescence microscopy

Q **, T Paunesku, B Lai, SC GLEBER… - Journal of …, 2017 - Wiley Online Library
Trace metals play important roles in biological function, and x‐ray fluorescence microscopy
(XFM) provides a way to quantitatively image their distribution within cells. The faithfulness …