Osteoporosis pathogenesis and treatment: existing and emerging avenues

B Liang, G Burley, S Lin, YC Shi - Cellular & Molecular Biology Letters, 2022 - Springer
Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

Targeting tumor and bone microenvironment: Novel therapeutic opportunities for castration-resistant prostate cancer patients with bone metastasis

S Li, Y Kang, Y Zeng - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Despite standard hormonal therapy that targets the androgen receptor (AR) attenuates
prostate cancer (PCa) effectively in the initial stage, the tumor ultimately converts to …

Bone‐targeted exosomes: strategies and applications

J Wang, X Li, S Wang, J Cui, X Ren… - Advanced Healthcare …, 2023 - Wiley Online Library
As the global population ages, bone‐related diseases have increasingly become a major
social problem threatening human health. Exosomes, as natural cell products, have been …

Glucose oxidase‐instructed biomineralization of calcium‐based biomaterials for biomedical applications

LH Fu, C Qi, T Sun, K Huang, J Lin, P Huang - Exploration, 2023 - Wiley Online Library
In recent years, glucose oxidase (GOx) has aroused great research interest in the treatment
of diseases related to abnormal glucose metabolisms like cancer and diabetes. However, as …

Near-infrared light control of GelMA/PMMA/PDA hydrogel with mild photothermal therapy for skull regeneration

Y Wu, X Zhang, B Tan, Y Shan, X Zhao, J Liao - Biomaterials Advances, 2022 - Elsevier
The development of bone tissue engineering indicates some new paths for bone defect
repair. Mild photothermal therapy (PTT) is flourishing as an exciting potential method for …

Nanoscale materials-based platforms for the treatment of bone-related diseases

X Zhang, S Koo, JH Kim, X Huang, N Kong, L Zhang… - Matter, 2021 - cell.com
Owing to the high density of bone tissue and the complex and highly hierarchical structure,
drugs used for the treatment of bone-related diseases are often not effectively concentrated …

NIR light-assisted phototherapies for bone-related diseases and bone tissue regeneration: A systematic review

Z Wan, P Zhang, L Lv, Y Zhou - Theranostics, 2020 - pmc.ncbi.nlm.nih.gov
Recently, the rapid development of biomaterials has induced great interest in the precisely
targeted treatment of bone-related diseases, including bone cancers, infections, and …

Alendronate-functionalized hypoxia-responsive polymeric micelles for targeted therapy of bone metastatic prostate cancer

M Long, X Liu, X Huang, M Lu, X Wu, L Weng… - Journal of Controlled …, 2021 - Elsevier
Bone metastasis is one of the leading causes of cancer-related death and remains incurable
in spite of great efforts. Bone-targeted nanoparticle-based drug carriers can overcome the …

Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects

D Natarajan, Z Ye, L Wang, L Ge… - Bioengineering & …, 2022 - Wiley Online Library
Bone grafts or prosthetic implant designing for clinical application is challenging due to the
complexity of integrated physiological processes. The revolutionary advances of …

Mesenchymal stem cell-derived extracellular vesicles: a regulator and carrier for targeting bone-related diseases

J Tang, X Wang, X Lin, C Wu - Cell Death Discovery, 2024 - nature.com
The escalating threat of bone-related diseases poses a significant challenge to human
health. Mesenchymal stem cell (MSC)-derived extracellular vesicles (MSC-EVs), as inherent …