Stress granules (SGs) are cytosolic biomolecular condensates that form in response to
cellular stress. Weak, multivalent interactions between their protein and RNA constituents …

RNA granules are mesoscale assemblies that form in the absence of limiting membranes.
RNA granules contain factors for RNA biogenesis and turnover and are often assumed to …

Endomembrane damage represents a form of stress that is detrimental for eukaryotic cells,.
To cope with this threat, cells possess mechanisms that repair the damage and restore …

The nucleolus is the largest biomolecular condensate and facilitates transcription,
processing, and assembly of ribosomal RNA (rRNA). Although nucleolar function is thought …

Biomolecular condensates are membraneless organelle-like structures that can concentrate
molecules and often form through liquid-liquid phase separation. Biomolecular condensate …

Heat-shocked cells prioritize the translation of heat shock (HS) mRNAs, but the underlying
mechanism is unclear. We report that HS in budding yeast induces the disassembly of the …

Oligodendrocyte (OL) injury and subsequent loss is a pathologic hallmark of multiple
sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs …

The cytoplasm is densely packed with molecules that contribute to its nonideal behavior.
Cytosolic crowding influences chemical reaction rates, intracellular water mobility, and …

Cells must sense and respond to sudden maladaptive environmental changes—stresses—
to survive and thrive. Across eukaryotes, stresses such as heat shock trigger conserved …

Once considered unconventional cellular structures, membraneless organelles (MLOs),
cellular substructures involved in biological processes or pathways under physiological …