Klebsiella pneumoniae infection biology: living to counteract host defences

JA Bengoechea, J Sa Pessoa - FEMS microbiology reviews, 2019 - academic.oup.com
Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae

RM Martin, MA Bachman - Frontiers in cellular and infection …, 2018 - frontiersin.org
Klebsiella pneumoniae is a Gram-negative pathogen that has a large accessory genome of
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …

Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver

X Huang, X Li, H An, J Wang, M Ding, L Wang… - PLoS …, 2022 - journals.plos.org
Polysaccharide capsule is the main virulence factor of K. pneumoniae, a major pathogen of
bloodstream infections in humans. While more than 80 capsular serotypes have been …

A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae

MF Feldman, AE Mayer Bridwell… - Proceedings of the …, 2019 - National Acad Sciences
Hypervirulent Klebsiella pneumoniae (hv Kp) is globally disseminating as a community-
acquired pathogen causing life-threatening infections in healthy individuals. The fact that a …

The making of hypervirulent Klebsiella pneumoniae

P Dai, D Hu - Journal of Clinical Laboratory Analysis, 2022 - Wiley Online Library
Klebsiella pneumoniae is a notorious bacterium in clinical practice. Virulence, carbapenem‐
resistance and their convergence among K. pneumoniae are extensively discussed in this …

A Klebsiella pneumoniae regulatory mutant has reduced capsule expression but retains hypermucoviscosity

KA Walker, TA Miner, M Palacios, D Trzilova… - MBio, 2019 - Am Soc Microbiol
The polysaccharide capsule is an essential virulence factor for Klebsiella pneumoniae in
both community-acquired hypervirulent strains as well as health care-associated classical …

Klebsiella pneumoniae: adaptive immune landscapes and vaccine horizons

PL Wantuch, DA Rosen - Trends in Immunology, 2023 - cell.com
Klebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing
nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood …

Clinical Implications of Genomic Adaptation and Evolution of Carbapenem-Resistant Klebsiella pneumoniae

A Gomez-Simmonds… - The Journal of infectious …, 2017 - academic.oup.com
Klebsiella pneumoniae poses a major challenge to healthcare worldwide as an important
cause of multidrug-resistant infections. Nosocomial clones, including epidemic sequence …

Encapsulation of bacteriophage in liposome accentuates its entry in to macrophage and shields it from neutralizing antibodies

S Singla, K Harjai, OP Katare, S Chhibber - PLoS One, 2016 - journals.plos.org
Phage therapy has been a centre of attraction for biomedical scientists to treat infections
caused by drug resistant strains. However, ability of phage to act only on extracellular …

Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2: O1 strains of Klebsiella …

PL Wantuch, CJ Knoot, LS Robinson… - PLoS …, 2023 - journals.plos.org
Klebsiella pneumoniae presents as two circulating pathotypes: classical K. pneumoniae (c
Kp) and hypervirulent K. pneumoniae (hv Kp). Classical isolates are considered urgent …