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[HTML][HTML] Breast cancer—epidemiology, risk factors, classification, prognostic markers, and current treatment strategies—an updated review
Simple Summary Breast cancer is the most common cancer among women. It is estimated
that 2.3 million new cases of BC are diagnosed globally each year. Based on mRNA gene …
that 2.3 million new cases of BC are diagnosed globally each year. Based on mRNA gene …
A compendium of mutational cancer driver genes
A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to develo** more efficient cancer detection methods and …
transformation. This is key to develo** more efficient cancer detection methods and …
Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline☆
Hereditary breast and ovarian cancer syndrome (HBOC) is clinically defined by family
history criteria, and molecularly defined by identification of germline pathogenic variants …
history criteria, and molecularly defined by identification of germline pathogenic variants …
Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions
Genetic variation can predispose to disease both through (i) monogenic risk variants that
disrupt a physiologic pathway with large effect on disease and (ii) polygenic risk that …
disrupt a physiologic pathway with large effect on disease and (ii) polygenic risk that …
Exome sequencing and characterization of 49,960 individuals in the UK Biobank
The UK Biobank is a prospective study of 502,543 individuals, combining extensive
phenotypic and genotypic data with streamlined access for researchers around the world …
phenotypic and genotypic data with streamlined access for researchers around the world …
Genetic testing and results in a population-based cohort of breast cancer patients and ovarian cancer patients
PURPOSE Genetic testing for cancer risk has expanded rapidly. We examined clinical
genetic testing and results among population-based patients with breast and ovarian …
genetic testing and results among population-based patients with breast and ovarian …
Breast cancer in men
SH Giordano - New England Journal of Medicine, 2018 - Mass Medical Soc
Breast Cancer in Men Breast cancer in men accounts for about 1% of all breast cancers and
is mainly estrogen-receptor–positive. Few prospective studies of treatment in men have …
is mainly estrogen-receptor–positive. Few prospective studies of treatment in men have …
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress
Cisplatin and its platinum analogs, carboplatin and oxaliplatin, are some of the most widely
used cancer chemotherapeutics. Although cisplatin and carboplatin are used primarily in …
used cancer chemotherapeutics. Although cisplatin and carboplatin are used primarily in …
Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
[HTML][HTML] Characterization of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program
Background Male breast cancer (BC) is rare, managed by extrapolation from female BC. The
International Male BC Program aims to better characterize and manage this disease. We …
International Male BC Program aims to better characterize and manage this disease. We …