Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004;
10.1152/physrev. 00014.2003.—One of the most significant challenges in neuroscience is to …

▪ Abstract Learning the relationships between aversive events and the environmental stimuli
that predict such events is essential to the survival of organisms throughout the animal …

The hippocampus is one of a group of remarkable structures embedded within the brain's
medial temporal lobe. Long known to be important for memory, it has been a prime focus of …

Bidirectional changes in the efficacy of neuronal synaptic transmission, such as
hippocampal long-term potentiation (LTP) and long-term depression (LTD), are thought to …

Abstract THE NMDA (TV-methyl-D-aspartate) receptor channel is important for synaptic
plasticity, which is thought to underlie learning, memory and development1, 2. The NMDA …

Recent data have demonstrated a biochemical sequence of events in the rat hippocampus
that is necessary for memory formation of inhibitory avoidance behavior. The sequence …

Learning and memory require the formation of new neural networks in the brain. A key
mechanism underlying this process is synaptic plasticity at excitatory synapses, which …

The synaptic vesicle cycle at the nerve terminal consists of vesicle exocytosis with neuro-
transmitter release, endocytosis of empty vesicles, and regeneration of fresh vesicles. Of all …

Cerebellar Purkinje cells exhibit a unique type of synaptic plasticity, namely, long-term
depression (LTD). When two inputs to a Purkinje cell, one from a climbing fiber and the other …

Summary mGluR1 mutant mice are viable but show characterlstic cerebellar symptoms such
as ataxlc galt and lntentlon tremor. The anatomy of the cerebellum Is not overtly dlsturbed …