Golgi structure and function in health, stress, and diseases
The Golgi apparatus is a central intracellular membrane-bound organelle with key functions
in trafficking, processing, and sorting of newly synthesized membrane and secretory proteins …
in trafficking, processing, and sorting of newly synthesized membrane and secretory proteins …
Adaptation of the Golgi apparatus in cancer cell invasion and metastasis
The Golgi apparatus plays a central role in normal cell physiology by promoting cell survival,
facilitating proliferation, and enabling cell-cell communication and migration. These roles …
facilitating proliferation, and enabling cell-cell communication and migration. These roles …
Organelle-specific initiation of cell death
In a majority of pathophysiological settings, cell death is not accidental—it is controlled by a
complex molecular apparatus. Such a system operates like a computer: it receives several …
complex molecular apparatus. Such a system operates like a computer: it receives several …
Knockout of the Golgi stacking proteins GRASP55 and GRASP65 impairs Golgi structure and function
Golgi reassembly stacking protein of 65 kDa (GRASP65) and Golgi reassembly stacking
protein of 55 kDa (GRASP55) were originally identified as Golgi stacking proteins; however …
protein of 55 kDa (GRASP55) were originally identified as Golgi stacking proteins; however …
Nonredundant Roles of GRASP55 and GRASP65 in the Golgi Apparatus and Beyond
X Zhang, Y Wang - Trends in biochemical sciences, 2020 - cell.com
It has been demonstrated that two Golgi stacking proteins, GRASP55 and GRASP65, self-
interact to form trans-oligomers that tether adjacent Golgi membranes into stacks and …
interact to form trans-oligomers that tether adjacent Golgi membranes into stacks and …
Hormesis, cell death and aging
Frequently, low doses of toxins and other stressors not only are harmless but also activate
an adaptive stress response that raise the resistance of the organism against high doses of …
an adaptive stress response that raise the resistance of the organism against high doses of …
GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion
It has been indicated that the Golgi apparatus contributes to autophagy, but how it is
involved in autophagosome formation and maturation is not well understood. Here we show …
involved in autophagosome formation and maturation is not well understood. Here we show …
Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation
VMS Betin, BK Singleton, SF Parsons, DJ Anstee… - Autophagy, 2013 - Taylor & Francis
Wholesale depletion of membrane organelles and extrusion of the nucleus are hallmarks of
mammalian erythropoiesis. Using quantitative EM and fluorescence imaging we have …
mammalian erythropoiesis. Using quantitative EM and fluorescence imaging we have …
Golgi fragmentation in ALS motor neurons. New mechanisms targeting microtubules, tethers, and transport vesicles
G Haase, C Rabouille - Frontiers in neuroscience, 2015 - frontiersin.org
Pathological alterations of the Golgi apparatus, such as its fragmentation represent an early
pre-clinical feature of many neurodegenerative diseases and have been widely studied in …
pre-clinical feature of many neurodegenerative diseases and have been widely studied in …
A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function
J McCaughey, NL Stevenson, JM Mantell… - Journal of Cell …, 2021 - journals.biologists.com
Complex machinery is required to drive secretory cargo export from the endoplasmic
reticulum (ER), which is an essential process in eukaryotic cells. In vertebrates, the MIA3 …
reticulum (ER), which is an essential process in eukaryotic cells. In vertebrates, the MIA3 …