DNA damage is the cause of numerous human pathologies including cancer, premature
aging, and chronic inflammatory conditions. The DNA damage response (DDR), in turn …

PCNA is the DNA sliding clamp found in eukaryotes and archaebacteria. Sliding clamps
were first described as processivity factors in DNA replication. They consist of multimeric …

During the bacterial cell cycle, chromosome replication and cell division must be
coordinated with overall cell growth in order to maintain the correct ploidy and cell size. The …

Evidence suggests that some nonsteroidal anti-inflammatory drugs (NSAIDs) possess
antibacterial properties with an unknown mechanism. We describe the in vitro antibacterial …

Abstract Highly conserved MutS and MutL homologs operate as protein dimers in mismatch
repair (MMR). MutS recognizes mismatched nucleotides forming ATP-bound sliding clamps …

We have investigated in vivo the role of the carboxy-terminal domain of the Bacillus subtilis
Single-Stranded DNA Binding protein (SSBCter) as a recruitment platform at active …

The ubiquitous sliding clamp facilitates processivity of the replicative polymerase and acts
as a platform to recruit proteins involved in replication, recombination and repair. While the …

Nineteen Thermococcus kodakarensis strains have been constructed, each of which
synthesizes a different His6-tagged protein known or predicted to be a component of the …

The sliding clamp is an essential component of the replisome required for processivity of
DNA synthesis and several other aspects of chromosome metabolism. However, the in vivo …

Bacterial chromosome replication is mainly catalyzed by DNA polymerase III, whose beta
subunits enable rapid processive DNA replication. Enabled by the clamp-loading complex …