Update on adipose tissue and cancer
Adipose tissue is the largest endocrine organ and an accepted contributor to overall energy
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …
homeostasis. There is strong evidence linking increased adiposity to the development of 13 …
Can't handle the stress? Mechanobiology and disease
Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …
properties influence biological systems at the cell, molecular, and tissue level, and how …
Cancer plasticity: investigating the causes for this agility
S Saha, N Pradhan, B Neha, R Mahadevappa… - Seminars in cancer …, 2023 - Elsevier
Cancer is not a hard-wired phenomenon but an evolutionary disease. From the onset of
carcinogenesis, cancer cells continuously adapt and evolve to satiate their ever-growing …
carcinogenesis, cancer cells continuously adapt and evolve to satiate their ever-growing …
Measuring and modelling tumour heterogeneity across scales
Cancer development, progression and therapy response are heterogeneous and patient-
specific. The biological and physical properties of tumour cells and their surrounding tissue …
specific. The biological and physical properties of tumour cells and their surrounding tissue …
An engineered model of metastatic colonization of human bone marrow reveals breast cancer cell remodeling of the hematopoietic niche
Incomplete understanding of metastatic disease mechanisms continues to hinder effective
treatment of cancer. Despite remarkable advancements toward the identification of …
treatment of cancer. Despite remarkable advancements toward the identification of …
Forcing the code: tension modulates signaling to drive morphogenesis and malignancy
Abstract Development and disease are regulated by the interplay between genetics and the
signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental …
signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental …
Structurally decoupled hyaluronic acid hydrogels for studying matrix metalloproteinase-mediated invasion of metastatic breast cancer cells
In recent years, polymeric hydrogels have been employed to investigate cancer cell-
extracellular matrix (ECM) interactions in vitro. In the context of breast cancer, cancer cells …
extracellular matrix (ECM) interactions in vitro. In the context of breast cancer, cancer cells …
Multimodal characterization of the collagen hydrogel structure and properties in response to physiologically relevant pH fluctuations
O Bronner-Shtrauchler, E Nativ-Roth, DS Sanchez… - Acta Biomaterialia, 2024 - Elsevier
Abstract pH fluctuations within the extracellular matrix (ECM) and its principal constituent
collagen, particularly in solid tumors and chronic wounds, may influence its structure and …
collagen, particularly in solid tumors and chronic wounds, may influence its structure and …
Breast tumor cell survival and morphology in a brain‐like extracellular matrix depends on matrix composition and mechanical properties
E Türker, MS Andrade Mier, J Faber… - Advanced …, 2024 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is the most invasive type of breast cancer with high
risk of brain metastasis. To better understand interactions between breast tumors with the …
risk of brain metastasis. To better understand interactions between breast tumors with the …
Deleterious mechanical deformation selects mechanoresilient cancer cells with enhanced proliferation and chemoresistance
Cancer cells in secondary tumors are found to form metastases more efficiently as compared
to their primary tumor counterparts. This is partially due to the unfavorable …
to their primary tumor counterparts. This is partially due to the unfavorable …