Chronic stress and A lzheimer's disease: the interplay between the hypothalamic–pituitary–adrenal axis, genetics and microglia

A Milligan Armstrong, T Porter, H Quek… - Biological …, 2021 - Wiley Online Library
Chronic psychosocial stress is increasingly being recognised as a risk factor for sporadic
Alzheimer's disease (AD). The hypothalamic–pituitary–adrenal axis (HPA axis) is the major …

From childhood adversity to latent stress vulnerability in adulthood: the mediating roles of sleep disturbances and HPA axis dysfunction

L Simon, R Admon - Neuropsychopharmacology, 2023 - nature.com
Childhood adversity is a prominent predisposing risk factor for latent stress vulnerability,
expressed as an elevated likelihood of develo** stress-related psychopathology upon …

[HTML][HTML] In vitro modeling of the neurobiological effects of glucocorticoids: A review

K Bassil, AC Krontira, T Leroy, AIH Escoto… - Neurobiology of …, 2023 - Elsevier
Hypothalamic-pituitary adrenal (HPA) axis dysregulation has long been implicated in stress-
related disorders such as major depression and post-traumatic stress disorder …

Gestational factors throughout fetal neurodevelopment: the serotonin link

SI Hanswijk, M Spoelder, L Shan, MMM Verheij… - International journal of …, 2020 - mdpi.com
Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders.
Fetal 5-HT levels can be influenced by several gestational factors, such as maternal …

[HTML][HTML] A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice

SA Torrisi, G Lavanco, OM Maurel, W Gulisano… - Neurobiology of …, 2021 - Elsevier
Translational animal models for studying post-traumatic stress disorder (PTSD) are valuable
for elucidating the poorly understood neurobiology of this neuropsychiatric disorder. These …

Involvement of nuclear factor-κB in inflammation and neuronal plasticity associated with post-traumatic stress disorder

S Gupta, RS Guleria - Cells, 2022 - mdpi.com
Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition which develops
either due to stress or witnessing a traumatic situation. PTSD is characterized by acute and …

Lifetime posttraumatic stress disorder as a predictor of mortality: a systematic review and meta-analysis

D Nilaweera, AZZ Phyo, AB Teshale, HL Htun… - BMC psychiatry, 2023 - Springer
Abstract Background Posttraumatic Stress Disorder (PTSD) could potentially increase the
risk of mortality, and there is a need for a meta-analysis to quantify this association. This …

Transcranial magnetic stimulation for post-traumatic stress disorder

AN Edinoff, TL Hegefeld, M Petersen… - Frontiers in …, 2022 - frontiersin.org
Post-traumatic stress disorder (PTSD) is a psychiatric disorder that causes significant
functional impairment and is related to altered stress response and reinforced learned fear …

“The facilitator is not a bystander”: exploring the perspectives of interdisciplinary experts on trauma research

S Hira, M Sheppard-Perkins, FE Darroch - Frontiers in psychology, 2023 - frontiersin.org
Objective This study investigates the concepts, knowledge, and guiding principles that
inform the practice of professionals researching trauma or working directly with individuals …

Mitochondrial DNA as a marker for treatment-response in post-traumatic stress disorder

EM Hummel, K Piovesan, F Berg, S Herpertz… - …, 2023 - Elsevier
Post-traumatic stress disorder (PTSD) is a serious mental health condition thought to be
mediated by a dysregulated stress response system. Stress, especially chronic stress …