The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …

The function of sperm is to safely transport the haploid paternal genome to the egg
containing the maternal genome. The subsequent fertilization leads to transmission of a new …

The conserved histone variant H2AZ has an important role in the regulation of gene
expression and the establishment of a buffer to the spread of silent heterochromatin. How …

▪ Abstract The past decade has seen an explosive increase in information about regulation
of eukaryotic gene transcription, especially for protein-coding genes. The most striking …

Various chemical modifications on histones and regions of associated DNA play crucial
roles in genome management by binding specific factors that, in turn, serve to alter the …

Two of the nucleosomal histone families, H3 and H2A, have highly conserved variants with
specialized functions. Recent studies have begun to elucidate the roles of two of the H2A …

Histones are best known as the architectural proteins that package the DNA of eukaryotic
organisms, forming octameric nucleosome cores that the double helix wraps tightly around …

In eukaryotes, DNA is organized together with histones and non-histone proteins into a
highly complex nucleoprotein structure called chromatin, with the nucleosome as its …

Stem cell division is essential for tissue integrity during growth, aging, and pathogenic
assaults. Adult gastrointestinal tract encounters numerous stimulations, and impaired tissue …

Activation of transcription within chromatin has been correlated with the incorporation of the
essential histone variant H2A. Z into nucleosomes. H2A. Z and other histone variants may …