Exploring pathological link between antimicrobial and amyloid peptides

Y Tang, Y Zhang, D Zhang, Y Liu, R Nussinov… - Chemical Society …, 2024 - pubs.rsc.org
Amyloid peptides (AMYs) and antimicrobial peptides (AMPs) are considered as the two
distinct families of peptides, characterized by their unique sequences, structures, biological …

A mechanistic survey of Alzheimer's disease

Y Tang, D Zhang, X Gong, J Zheng - Biophysical chemistry, 2022 - Elsevier
Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …

[HTML][HTML] Cognitive enhancement and neuroprotective effects of OABL, a sesquiterpene lactone in 5xFAD Alzheimer's disease mice model

JJ Tang, LF Huang, JL Deng, YM Wang, C Guo… - Redox biology, 2022 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease in which oxidative stress and
neuroinflammation were demonstrated to be associated with neuronal loss and cognitive …

[HTML][HTML] Antimicrobial peptides (AMPs) in the pathogenesis of Alzheimer's disease: implications for diagnosis and treatment

F Bruno, A Malvaso, S Canterini, AC Bruni - Antibiotics, 2022 - mdpi.com
Alzheimer's disease (AD) represents the most frequent type of dementia in elderly people.
There are two major forms of the disease: sporadic (SAD)—whose causes are not …

SEVI inhibits Aβ amyloid aggregation by cap** the β-sheet elongation edges

Y Wang, J Xu, F Huang, J Yan, X Fan… - Journal of chemical …, 2023 - ACS Publications
Inhibiting the aggregation of amyloid peptides with endogenous peptides has broad interest
due to their intrinsically high biocompatibility and low immunogenicity. Here, we investigated …

[HTML][HTML] Neurodegenerative microbially-shaped diseases: oxidative stress meets neuroinflammation

DF Silva, N Empadinhas, SM Cardoso, AR Esteves - Antioxidants, 2022 - mdpi.com
Inflammation and oxidative stress characterize a number of chronic conditions including
neurodegenerative diseases and aging. Inflammation is a key component of the innate …

Spatiotemporally controlled calcitonin delivery: Long-term and targeted therapy of skeletal diseases

P Yu, Y Liu, J **e, J Li - Journal of Controlled Release, 2021 - Elsevier
Bone is a connective tissue that support the entire body and protect the internal organs.
However, there are great challenges on curing intractable skeletal diseases such as …

Hydrophobic/hydrophilic ratio of amphiphilic helix mimetics determines the effects on islet amyloid polypeptide aggregation

H Tang, Y Sun, F Ding - Journal of chemical information and …, 2022 - ACS Publications
Amyloid depositions of human islet amyloid polypeptides (hIAPP) are associated with type II
diabetes (T2D) impacting millions of people globally. Accordingly, strategies against hIAPP …

Interplay between Antimicrobial Peptides and Amyloid Proteins in Host Defense and Disease Modulation

NA Wani, E Gazit, A Ramamoorthy - Langmuir, 2024 - ACS Publications
The biological properties of antimicrobial peptides (AMPs) and amyloid proteins and their
cross-talks have gained increasing attention due to their potential implications in both host …

Cross-seeding between Aβ and SEVI indicates a pathogenic link and gender difference between alzheimer diseases and AIDS

Y Tang, D Zhang, Y Zhang, Y Liu, Y Miller… - Communications …, 2022 - nature.com
Amyloid-β (Aβ) and semen-derived enhancer of viral infection (SEVI) are considered as the
two causative proteins for central pathogenic cause of Alzheimer's disease (AD) and …