Microglia continuously survey the brain parenchyma and actively shift status following
stimulation. These processes demand a unique bioenergetic programme; however, little is …

Accumulation of amyloid β-peptide (Aβ) is a driver of Alzheimer's disease (AD). Amyloid
precursor protein (App) knock-in mouse models recapitulate AD-associated Aβ pathology …

Alzheimer's disease (AD) is characterized by extensive neurodegeneration and
inflammation in selective brain areas, linked to severely disabling cognitive deficits. Before …

Abstract Systems biology and systems neurophysiology generate comprehensive
mechanistic models of the spatial-temporal evolution of body system networks from …

Background Cognitive impairment is a common symptom of Parkinson's disease (PD) that
increases in risk and severity as the disease progresses. An accurate prediction of the risk of …

Background Dynamically altered microglia play an important role in the progression of
Alzheimer's disease (AD). Here, we found a close association of the metabolic …

Objectives Mild cognitive impairment presenting with an amnestic syndrome (aMCI) and
amyloid positivity is considered due to AD. Many subjects, however, can show an overall …

Abstract Background/Objectives The link between obesity and brain function is a fascinating
but still an enigmatic topic. We evaluated the effect of Roux-en-Y gastric bypass (RYGB) on …

Objective To evaluate the progression of brain glucose metabolism among participants with
biological signature of Alzheimer's disease (AD) and its relevance to cognitive decline …

Alterations of cerebral glucose metabolism can be detected in patients with isolated rapid
eye movement sleep behaviour disorder, a prodromal feature of neurodegenerative …