Recent progress in the development of fluorescent probes for imaging pathological oxidative stress

Y Geng, Z Wang, J Zhou, M Zhu, J Liu… - Chemical Society …, 2023 - pubs.rsc.org
Oxidative stress is closely related to the physiopathology of numerous diseases. Reactive
oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) …

Oxidative stress and antioxidants in neurodegenerative disorders

EO Olufunmilayo, MB Gerke-Duncan, RMD Holsinger - Antioxidants, 2023 - mdpi.com
Neurodegenerative disorders constitute a substantial proportion of neurological diseases
with significant public health importance. The pathophysiology of neurodegenerative …

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease

BG Trist, DJ Hare, KL Double - Aging cell, 2019 - Wiley Online Library
Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …

Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …

MG Savelieff, G Nam, J Kang, HJ Lee, M Lee… - Chemical …, 2018 - ACS Publications
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Preventing Parkinson's disease: an environmental agenda

BR De Miranda, SM Goldman… - Journal of …, 2022 - journals.sagepub.com
Fueled by aging populations and continued environmental contamination, the global burden
of Parkinson's disease (PD) is increasing. The disease, or more appropriately diseases …

The role of oxidative stress in Parkinson's disease

V Dias, E Junn, MM Mouradian - Journal of Parkinson's …, 2013 - content.iospress.com
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Mitochondrial dysfunction in Parkinson's disease—cause or consequence?

C Chen, DM Turnbull, AK Reeve - Biology, 2019 - mdpi.com
James Parkinson first described the motor symptoms of the disease that took his name over
200 years ago. While our knowledge of many of the changes that occur in this condition has …

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

SR Subramaniam, MF Chesselet - Progress in neurobiology, 2013 - Elsevier
Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …

Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases—a mechanistic approach

MT Baltazar, RJ Dinis-Oliveira, M de Lourdes Bastos… - Toxicology letters, 2014 - Elsevier
The etiology of most neurodegenerative disorders is multifactorial and consists of an
interaction between environmental factors and genetic predisposition. The role of pesticide …

A guide to neurotoxic animal models of Parkinson's disease

K Tieu - Cold Spring Harbor perspectives in …, 2011 - perspectivesinmedicine.cshlp.org
Parkinson's disease (PD) is a neurological movement disorder primarily resulting from
damage to the nigrostriatal dopaminergic pathway. To elucidate the pathogenesis …