Pathophysiology of chronic graft-versus-host disease and therapeutic targets

R Zeiser, BR Blazar - New England Journal of Medicine, 2017 - Mass Medical Soc
Chronic GVHD, an autoimmune disease that follows allogeneic hematopoietic-cell
transplantation, is characterized by infections and debilitating tissue injury leading to …

[HTML][HTML] The biology of chronic graft-versus-host disease: a task force report from the National Institutes of Health Consensus Development Project on Criteria for …

KR Cooke, L Luznik, S Sarantopoulos, FT Hakim… - Biology of Blood and …, 2017 - Elsevier
Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …

Current concepts and advances in graft-versus-host disease immunology

GR Hill, BC Betts, V Tkachev, LS Kean… - Annual review of …, 2021 - annualreviews.org
Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell
transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency …

CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment

RA Drummond, M Swamydas, V Oikonomou… - Nature …, 2019 - nature.com
The C-type lectin receptor–Syk (spleen tyrosine kinase) adaptor CARD9 facilitates protective
antifungal immunity within the central nervous system (CNS), as human deficiency in …

Chronic graft-versus-host disease: biological insights from preclinical and clinical studies

KPA MacDonald, GR Hill… - Blood, The Journal of the …, 2017 - ashpublications.org
With the increasing use of mismatched, unrelated, and granulocyte colony-stimulating factor–
mobilized peripheral blood stem cell donor grafts and successful treatment of older …

New approaches for the treatment of chronic graft-versus-host disease: current status and future directions

NEB Saidu, C Bonini, A Dickinson, M Grce… - Frontiers in …, 2020 - frontiersin.org
Chronic graft-versus-host disease (cGvHD) is a severe complication of allogeneic
hematopoietic stem cell transplantation that affects various organs leading to a reduced …

Carbon nanotube recognition by human Siglec-14 provokes inflammation

SI Yamaguchi, Q **e, F Ito, K Terao, Y Kato… - Nature …, 2023 - nature.com
For the design and development of innovative carbon nanotube (CNT)-based tools and
applications, an understanding of the molecular interactions between CNTs and biological …

Role of B-cell in the pathogenesis of systemic sclerosis

B Thoreau, B Chaigne, L Mouthon - Frontiers in Immunology, 2022 - frontiersin.org
Systemic sclerosis (SSc) is a rare multisystem autoimmune disease, characterized by
fibrosis, vasculopathy, and autoimmunity. Recent advances have highlighted the significant …

Human CARD9: a critical molecule of fungal immune surveillance

RA Drummond, LM Franco, MS Lionakis - Frontiers in immunology, 2018 - frontiersin.org
CARD9 is a signaling adaptor protein that is involved in the transduction of signals from a
variety of innate pattern recognition receptors, including the C-type lectin receptors and …

Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD

BR Blazar, GR Hill, WJ Murphy - Nature Reviews Clinical Oncology, 2020 - nature.com
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) was the first successful
therapy for patients with haematological malignancies, predominantly owing to graft-versus …