Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …

Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures
and whole-animal systems. By mimicking features of the in vivo environment and taking …

Mammalian organs are challenging to study as they are fairly inaccessible to experimental
manipulation and optical observation. Recent advances in three-dimensional (3D) culture …

The extracellular matrix (ECM) regulates cell behavior by influencing cell proliferation,
survival, shape, migration and differentiation. Far from being a static structure, the ECM is …

Epithelial organs are built through the movement of groups of interconnected cells. We
observed cells in elongating mammary ducts reorganize into a multilayered epithelium …

Many embryonic organs undergo epithelial morphogenesis to form tree-like hierarchical
structures. However, it remains unclear what drives the budding and branching of stratified …

For all animals, cell migration is an essential and highly regulated process. Cells migrate to
shape tissues, to vascularize tissues, in wound healing, and as part of the immune …

Cells of the mammary gland are in intimate contact with other cells and with the extracellular
matrix (ECM), both of which provide not only a biochemical context, but a mechanical …

Via integrins, cells can sense dimensionality and other physical and biochemical properties
of the extracellular matrix (ECM). Cells respond differently to two-dimensional substrates …

Cell migration results from stepwise mechanical and chemical interactions between cells
and their extracellular environment. Mechanistic principles that determine single-cell and …